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젊은 연령에서 발병한 당뇨병 환자의 임상 및 면역유전학적 특성과 기저 C-펩타이드의 추적관찰
DC Field | Value | Language |
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dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.date.accessioned | 2019-11-26T01:00:44Z | - |
dc.date.available | 2019-11-26T01:00:44Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1015-6461 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172661 | - |
dc.description.abstract | BACKGROUND: This study was undertaken to observe the changes of basal C-peptide level and to compare the clinical and immunogenetic characteristics in newly dignosed young age-onset diabetics in Korea. We studied predictors effecting the change of insulin secretory capacity in these patients. METHODS: 82 newly diagnosed young diabetic patients (mean age; 23.0+7.1, M:F=46:36) were divided into 3 groups according to the initial fasting serum C-peptide level (Classification I, group 1; C-peptide < 0.6 ng/mL, group 2; 0.6 ng/mL C-peptide <1.2 ng/mL, and group 3; 1.2 ng/mL C-peptide) and reclassified by the follow-up (mean follow-up; 3.7 year) fasting serum C-peptide level. RESULTS: According to the initial fasting serum C-peptide level, 17.1% (14/82) of the patients were classified as group 1, 35.4% (29/82) as group 2, and 47.5%(39/82) as group 3. In group 3, body mass index (BMI, p<0.01) and maximal BMI (p<0.01) at onset, family history of diabetes (p=0.01) and stimulated C-peptide increment were significantly higher than those in group 1 and 2. Presence of urine ketone (p<0.01), history of diabetic keto- acidosis (p<0.01), and frequency of insulin therapy at diagnosis (p<0.01) were significantly lower than those in group 1 and 2. No significant differences in onset age, sex, weight loss at onset, HbA1c, anti GAD antibody and HLA-DR were found among the 3 groups. After certain follow-up periods, 37.8% (31/82) of the patients were reclassified as group 1, 24.4% (20/82) as group 2, and 37.8% (31/82) as group 3 according to the follow-up fasting serum C-peptide level(classification II). All of the patients in group 1 in classification I were reclassified as group 1 in classification II. In group 2, 44.8% were reclassified as group 1 and 17.3% were reclassified in group 3. In group 3, 15.4% (6/39) of patients showed a significant decrease in insulin secretory capacity and were reclassified as type I diabetes, and their predictors for decreased insulin secretory capacity were low BMI at onset, low slimulated C-peptide increment, and antiGAD antibody. CONCLUSION: Our study showed that classification of newly diagnosed young diabetics by fasting C-peptide level is not always easy. Therefore follow-up measurement of C-peptide and consideration of clinical characteristics are needed in discriminating the type of diabetes in these groups of diabetics in Korea. | - |
dc.description.statementOfResponsibility | prohibition | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 대한당뇨병학회 | - |
dc.relation.isPartOf | Journal of Korean Diabetes Association (당뇨병) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 젊은 연령에서 발병한 당뇨병 환자의 임상 및 면역유전학적 특성과 기저 C-펩타이드의 추적관찰 | - |
dc.title.alternative | Floow-up Study of Clinical and Immunogenetic Chracteristics and Basal C-peptidein Korea Young Age Onset Diabetic Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 김현수 | - |
dc.contributor.googleauthor | 안철우 | - |
dc.contributor.googleauthor | 권진욱 | - |
dc.contributor.googleauthor | 장경희 | - |
dc.contributor.googleauthor | 박석원 | - |
dc.contributor.googleauthor | 남수연 | - |
dc.contributor.googleauthor | 남재현 | - |
dc.contributor.googleauthor | 송영득 | - |
dc.contributor.googleauthor | 임승길 | - |
dc.contributor.googleauthor | 김경래 | - |
dc.contributor.googleauthor | 이현철 | - |
dc.contributor.googleauthor | 김덕희 | - |
dc.contributor.googleauthor | 허갑범 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.relation.journalcode | J01508 | - |
dc.subject.keyword | Young age onset diabetics | - |
dc.subject.keyword | C-peptide | - |
dc.subject.keyword | Follow-up study | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | 안철우 | - |
dc.contributor.affiliatedAuthor | 이현철 | - |
dc.citation.volume | 23 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 288 | - |
dc.citation.endPage | 298 | - |
dc.identifier.bibliographicCitation | Journal of Korean Diabetes Association (당뇨병), Vol.23(3) : 288-298, 1999 | - |
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