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Prevalence of anti-beta2 glycoprotein-I antibody in patients with primary or secondary immune thrombocytopenia
DC Field | Value | Language |
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dc.contributor.author | 김현숙 | - |
dc.date.accessioned | 2019-11-26T00:57:14Z | - |
dc.date.available | 2019-11-26T00:57:14Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0953-7104 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172607 | - |
dc.description.abstract | We determined the prevalence of antibodies to beta(2) glycoprotein-I (beta(2) GPI) in sera of 57 patients with primary or secondary immune thrombocytopenia positive for platelet antibody (PAIgG) and in 16 healthy control subjects. Both isotypes (IgG and IgM) of anti-beta(2) GPI were detected by means of semiquantitative ELISA and platelet antibodies were measured by means of flow cytometry using FITC-labeled anti-human IgG. Six (10.5%) of 57 patients with immune thrombocytopenia had anti-beta(2) GPI, whereas none of the 16 healthy subjects had anti-beta(2) GPI. Four were positive for IgM anti-beta(2) GPI, one for IgG anti-beta(2) GPI, and one was positive both for IgM and IgG anti-beta(2) GPI. There was no significant association between the presence of anti-beta(2) GPI and the severity of thrombocytopenia. Our findings suggest that some patients with immune thrombocytopenia have anti-beta(2) GPI in addition to the increased PAIgG; however, the results do not support a major role for anti-beta(2) GPI in the pathogenesis of immune thrombocytopenia. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | PLATELETS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Prevalence of anti-beta2 glycoprotein-I antibody in patients with primary or secondary immune thrombocytopenia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Kyung Soon Song | - |
dc.contributor.googleauthor | Young Ah Kim | - |
dc.contributor.googleauthor | Hyon Suk Kim | - |
dc.contributor.googleauthor | Jae Gyun Lim | - |
dc.contributor.googleauthor | Hyun Kyung Kim | - |
dc.contributor.googleauthor | Kwang Il Park | - |
dc.contributor.googleauthor | Quehn Park | - |
dc.identifier.doi | 10.1080/09537109976059 | - |
dc.contributor.localId | A01117 | - |
dc.relation.journalcode | J02535 | - |
dc.identifier.eissn | 1369-1635 | - |
dc.identifier.pmid | 16801095 | - |
dc.identifier.url | https://www.tandfonline.com/doi/abs/10.1080/09537109976059 | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | 김현숙 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 219 | - |
dc.citation.endPage | 222 | - |
dc.identifier.bibliographicCitation | PLATELETS, Vol.10(4) : 219-222, 1999 | - |
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