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경증 및 중등증 지속형 기관지천식 환자에서 알레지온(Epinastine HCI)의 임상효과

Other Titles
 Clinical effect of Alesion (epinastine HCI) on mild to moderate persistent bronchial asthma 
Authors
 박중원  ;  김철우  ;  홍천수 
Citation
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.20(6) : 887-894, 2000 
Journal Title
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기) 
ISSN
 1226-8739 
Issue Date
2000
Keywords
Alesion ; Epinastine ; Asthma
Abstract
BACKGROUND: Alesion, which is known as one of the second generation anti-histamine agents, has diverse anti-allergic effects. Some investigators have reported the clinical effects of Alesion as acting like an addictive agents to inhaled steroid in mild to moderate persistent bronchial asthma. METHODS: We evaluated the additive effects of daily administration of 20 mg of Alesion (epinastine HCl) in 30 mild to moderate persistent bronchial asthma patients. We estimated the clinical effects of Alesion with symptom scores, morning PEFR without bronchodilator, sputum eosinophil counts of induced sputum, spirometer parameters and frequency of short acting 2 agonist inhalation. RESULTS: With administration of Alesion for 4 weeks, the score of dyspnea, cough, nocturnal symptoms and limitation of daily activity were significantly improved. The mean value of morning PEFR without bronchodilator was also significantly improved by administration of Alesion. These improvements appeared after 1 week of administration. But, the frequencies of short acting 2 agonist inhalation, FEV1, FVC, peripheral blood eosinophil count, eosinophil percentage of induced sputum were not changed by the Alesion. About 64% of the enrolled patients expressed the clinical effects of Alesion. The patients complained of headache (1 case), drowsiness or sleepiness (3 cases), and weight gain (1 case) as adverse effects of Alesion. CONCLUSIONS: We suggest that Alesion can be effective as an the additive agent in mild to moderate persistent degree of bronchial asthma.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Hong, Chein Soo(홍천수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172510
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