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신경병증성통증 모델쥐에서 냉자극 유발 통증의 교감신경성 의존도
DC Field | Value | Language |
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dc.contributor.author | 임중우 | - |
dc.date.accessioned | 2019-11-11T06:15:16Z | - |
dc.date.available | 2019-11-11T06:15:16Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 2005-9159 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172398 | - |
dc.description.abstract | Background: Peripheral nerve injury sometimes leads to chronic neuropathic pain such as causalgia. A subset of patients with causalgia have a sympathetically maintained pain which is often evoked by cooling stimuli. However, our knowledge on adrenergic receptor types responsible for cold-evoked pain that is sympathetically dependent is lacking. The present study was conducted to investigate subtypes of adrenoceptors involved in mediating cold-evoked pain that developed following peripheral #nerve injury. Methods: Neuropathic surgery was performed by a unilateral ligation of LS and L6 spinal nerves of rats. Behavioral sign of cold-evoked pain was examined for 5 min by measuring cumulative duration of time that the rat lifted its foot off a metal plate held at cold temperature (5℃). Whether cold-evoked pain behavior was affected by antagonists of various subtypes of adrenoceptors, which were administered intraperitoneally before and after the ligation, was investigated. Results: After ligation, duration of foot lifting on the ligated side at cold temperature increased as compared to the pre-operative period. This increase maintained for the entire 40-day test period. Pretreatment with alpha-antagonist phentolamine produced a suppression of cold-evoked pain behavior that was not affected by beta-antagonist propranolol pretreatment. Prazosin, alpha-1 antagonist, suppressed cold-evoked pain behavior when treated either before or after nerve ligation. On the other hand, alpha-2 antagonist yohimbine was without effect on cold-evoked pain behavior whether it was treated before or after the ligation. Conclusions: The results suggest that peripheral nerve injury develops cold-evoked pain that is sympathetically dependent, and that alpha-1 adrenoreceptor plays a critical role for the generation of this type of pain in its initiation as well as maintenance. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 대한통증학회 | - |
dc.relation.isPartOf | Korean Journal of Pain (대한통증학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 신경병증성통증 모델쥐에서 냉자극 유발 통증의 교감신경성 의존도 | - |
dc.title.alternative | Sympathetic Dependency of Cold-evoked Pain Behavior Seen in Rats with Peripheral Neuropathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.googleauthor | 최병욱 | - |
dc.contributor.googleauthor | 최윤 | - |
dc.contributor.googleauthor | 곽영섭 | - |
dc.contributor.googleauthor | 남택상 | - |
dc.contributor.googleauthor | 백광세 | - |
dc.contributor.googleauthor | 임중우 | - |
dc.contributor.localId | A03409 | - |
dc.relation.journalcode | J03702 | - |
dc.identifier.eissn | 2093-0569 | - |
dc.subject.keyword | Adrenoceptor | - |
dc.subject.keyword | Causalgia | - |
dc.subject.keyword | Nerve injury | - |
dc.subject.keyword | Neuropathic pain | - |
dc.contributor.alternativeName | Leem, Joong Woo | - |
dc.contributor.affiliatedAuthor | 임중우 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 156 | - |
dc.citation.endPage | 163 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pain (대한통증학회지), Vol.13(2) : 156-163, 2000 | - |
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