위에 발생한 인환세포암의 임상병리학적 특성 및 예후.

Abstract

PURPOSE: There has been considerable controversy over the prognosis of gastric signet ring cell carcinoma (SRC). To clarify the biologic behavior of SRC, we evaluated the clinicopathologic features and the prognosis of SRC. METHODS: A total of 3,104 patients with a gastric carcinoma who had undergone a gastrectomy from 1987 to 1995 were analyzed retrospectively. Among them, 556 patients with SRC were compared to 2,548 patients with non-SRC. RESULTS: Patients with SRC were younger than those with non-SRC, and female were prevalent. Incidence of EGC were higher in patients with SRC. EGC with SRC had a larger proportion of mucosa-confined lesions and a lower rate of lymph node metastasis than EGC with non-SRC. Multivariate analysis showed that SRC was a negative inde pendent risk factor for lymph node metastasis. Among advanced gastric cancers SRCs showed a higher prevalence of large-sized lesions, Borrmann type IV lesions, and advanced nodal stage, as well as a higher rate of peritoneal metastasis. The 5-year survival rate of EGC with SRC (93.8%) was higher than that of non-SRC (91.2%). However, the prognosis of advanced SRC (49.0%) was poorer than that of non-SRC (53.5%). CONCLUSION: A female preponderance, a younger age, and a higher proportion of early gastric cancer characterized the peculiar biologic behavior of gastric signet ring cell carcinoma. In addi tion, the prognosis of SRC was poor once invasion had gone beyond the submucosa. These findings suggest that signet ring cell carcinoma of the stomach should be regarded as a distinct type of gastric cancer.