80 203

Cited 0 times in

이차성 부갑상선 기능 항진증이 있는 지속성 외래 복막투석 환자에서 칼시트리올 경구 충격요법과 저용량 매일 요법의 비교연구

DC Field Value Language
dc.contributor.author최규헌-
dc.date.accessioned2019-11-11T05:52:56Z-
dc.date.available2019-11-11T05:52:56Z-
dc.date.issued2000-
dc.identifier.issn1225-0015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/172234-
dc.description.abstractThe most widely used method for treatment of secondary hyperparathyroidism(SH) in CAPD patients has been the administration of calcitriol by oral route. In this study, we compared the efficacy and safety of daily low dose calcitriol therapy with those of intermittent high dose pulse therapy. The study group consisted of 38 patients undergoing CAPD with serum intact PTH level of more than 200pg/mL. Twenty patients were randomly administered daily low dose calcitriol(0.25㎍/day for 1 month followed by 0.5㎍ daily dose for the next 3 months) while 18 patients were given intermittent pulse therapy(0.5㎍-0.5㎍-0.75㎍ 3 times a week for 1 month, increased to 1.0㎍-1.25㎍ 3 times a week for the next 3 months). Thirty five patients completed the study : 17 on daily oral calcitriol (M : F=0.7 : 1, mean age=47.3±10.6 years, mean duration of CAPD=48.9±41.1 months), and 18 on oral pulse calcitriol(M : F=1.6 : 1, mean age=41.5±12.7 years, mean duration of CAPD=49.2±41.6 months). The baseline serum levels of calcium, phosphorus, i-PTH, alkaline phosphotase, and total CO2 were not different between daily and pulse group(9.5±0.8 vs 9.3±0.9 ㎎/dL, 5.8±1.3 vs 5.1±1.2㎎/dL, 443.1±162.5 vs 546.±385.9pg/mL, 91.8±47.7 vs 108.9± 66.5IU/L, 23.7±1.9 vs 25.5±2.0mEq/L, p>0.05, respectively). The i-PTH level decreased significantly in daily calcitriol group after 1 month(332.8±214.8pg/mL, p<0.01), and at final evaluation(180±254.8pg/mL, p<0.01). In pulse calcitriol group, i-PTH level also decreased significantly to 400.4±225.8pg/mL(p<0.05), 89.4±122.6 pg/mL(p<0.01), respectively. The rate of decline in i-PTH level from baseline were similar(daily=25.4± 22.7 vs pulse=19.5±12.6%decline.month, p>0.05). The serum calcium increased similarly in both groups after treatment(daily=10.6±0.8 vs pulse=10.1±1.0㎎/dL, p>0.05). Hypercalcemia(>11.0㎎/dL) was rarely observed in all patients(daily=5, pulse=8 episodes). In conclusion, both daily and pulse calcitriol therapy were similarly effective and safe in control of SH.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한신장학회-
dc.relation.isPartOfKorean Journal of Nephrology (대한신장학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title이차성 부갑상선 기능 항진증이 있는 지속성 외래 복막투석 환자에서 칼시트리올 경구 충격요법과 저용량 매일 요법의 비교연구-
dc.title.alternativeComparison between Oral Pulse and Daily Calcitriol (Calcio) Therapy in Continuous Ambrlatory Peritoneal Dialysis (CAPD) Patients with Secondary Hyperparathyroidism-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthor류동렬-
dc.contributor.googleauthor노현진-
dc.contributor.googleauthor유태현-
dc.contributor.googleauthor노현정-
dc.contributor.googleauthor윤향숙-
dc.contributor.googleauthor황재하-
dc.contributor.googleauthor송현용-
dc.contributor.googleauthor신석균-
dc.contributor.googleauthor강신욱-
dc.contributor.googleauthor최규헌-
dc.contributor.googleauthor하성규-
dc.contributor.googleauthor이호영-
dc.contributor.googleauthor한대석-
dc.contributor.localIdA04043-
dc.relation.journalcodeJ02066-
dc.subject.keywordCalcitriol-
dc.subject.keywordSecondary hyperparathyroidism-
dc.subject.keywordCAPD-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.affiliatedAuthor최규헌-
dc.citation.volume19-
dc.citation.number3-
dc.citation.startPage509-
dc.citation.endPage517-
dc.identifier.bibliographicCitationKorean Journal of Nephrology (대한신장학회지), Vol.19(3) : 509-517, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.