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불임 환자에 있어서 황체형성호르몬에 관한 유전자 분석
DC Field | Value | Language |
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dc.contributor.author | 배상욱 | - |
dc.contributor.author | 이병석 | - |
dc.date.accessioned | 2019-11-11T05:45:56Z | - |
dc.date.available | 2019-11-11T05:45:56Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0494-4755 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172147 | - |
dc.description.abstract | Objectives : To investigate the presence of LH-β gene mutaion in women with infertility by analyzing the gene sequence of LH-β subunit. Materials and Methods : From June 1999 to March 2000, nuclear DNA was extracted from peripheral blood samples of 32 women infertility patients and the exon 3 of LH-β subunit gene was replicated by PCR(Polymerase Chain Reaction). The product of PCR was analyzed for the presence of point mutation from G1502 to A1502 within the LH-βsubunit gene by RFLP(Restriction Fragment Length Polymorphism). Additionally Direct PCR mediated DNA sequencing was performed. Result : In the 32 infertility women studied, the point mutation from G1502 to A1502 was not present and 2 normal bands were observed on RFLP. Conclusion : The purpose of this study was to investigate whether a point mutation from G1502 to A1502 is present in women with infertility. Very few cases of LH-β gene mutation have been reported, and since the site of point mutation is highly variable, identifying and localzing LH-β gene mutation should be difficult and further studies must be conducted | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | Korean | - |
dc.publisher | 대한산부인과학회 | - |
dc.relation.isPartOf | Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 불임 환자에 있어서 황체형성호르몬에 관한 유전자 분석 | - |
dc.title.alternative | LH-B gene analysis in infertility patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | 김정연 | - |
dc.contributor.googleauthor | 박기현 | - |
dc.contributor.googleauthor | 배상욱 | - |
dc.contributor.googleauthor | 이병석 | - |
dc.contributor.googleauthor | 안용호 | - |
dc.contributor.localId | A01793 | - |
dc.contributor.localId | A02795 | - |
dc.relation.journalcode | J02075 | - |
dc.identifier.url | http://kiss.kstudy.com/thesis/thesis-view.asp?key=1857761 | - |
dc.subject.keyword | PCR RFLP | - |
dc.subject.keyword | Infertility | - |
dc.subject.keyword | LH-βgene mutation | - |
dc.subject.keyword | PCR | - |
dc.subject.keyword | LH-β Subunit mutation | - |
dc.subject.keyword | PCR | - |
dc.contributor.alternativeName | Bai, Sang Wook | - |
dc.contributor.affiliatedAuthor | 배상욱 | - |
dc.contributor.affiliatedAuthor | 이병석 | - |
dc.citation.volume | 43 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1389 | - |
dc.citation.endPage | 1393 | - |
dc.identifier.bibliographicCitation | Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.43(8) : 1389-1393, 2000 | - |
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