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자궁내막증식증과 자궁내막선암에서의 bcl-2와 bax 단백질의 발현

Other Titles
 Bcl-2 and bax expression in endometrial hyperplasia and adenocarcinoma 
 이병석  ;  홍순옥  ;  양우익  ;  이지성  ;  차동현  ;  조용선  ;  김정연  ;  박기현  ;  조동제  ;  송찬호 
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.43(9) : 1574-1580, 2000 
Journal Title
Korean Journal of Obstetrics and Gynecology(대한산부인과학회잡지)
Issue Date
Bcl-2 ; Bax ; Apoptosis ; Apoptosis ; Endometrial hyperplasia ; Adenocarcinoma
Objective : To investigate the distribution of bcl-2 and bax proteins in the endometrial neoplastic tissues in order to find out the role of these two genes in causing the neoplasia.Methods: Formalin-fixed, paraffin-embedded tissue blocks were retrieved from the surgical pathology files of the Department of Pathology, College of Medicine, Yonsei University, for the period from 1992 through 1997. We selected cases of endometrial hyperplasia without atypia(n=30), hyperplasia with atypia(n=10), and endometrial adenocarcinoma, grade I(n=23), grade II(n=15), grade III(n=11). Immunohistochemical staining was performed to detect the expression of bcl-2 and bax proteins. Results : Bcl-2 was expressed in all cases of endometrial hyperplasia without atypia(100.0%). In endometrial hyperplasia with atypia, bcl-2 was expressed in 7 cases out of 10 cases(70.0%). The intensity of bcl-2 was stronger in hyperplasia without atypia. Bax was expressed in 29 cases out of 30 cases in endometrial hyperplasia without atypia(96.7%). In endometrial hyperplasia with atypia, bax was expressed in 6 cases out of 10 cases(60.0%). The expression, the intensity, and the percentage of positive tumor cells of bcl-2 were decreased as the grade advanced in endometrial adenocarcinoma. However, there was no difference in the expression of bax. Conclusion : Bcl-2 and bax may play a role in keeping transformed cells alive in premalignant endometrial lesion. Furthermore, bcl-2 may be involved in the differentiation of the endometrial cancer cells and may be used as a prognostic factor in endometrial cancer.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
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