Wilm 종양의 예후인자와 술전 및 재발시 사용된 항암약물에 따른 생존율의 차이

Abstract

Purpose: We evaluated the prognostic factors of Wilms` tumor and reviewed the survival rate by several chemotherapeutic drugs used in recurred group.Materials and Methods: We reviewed the records of 53 patients with Wilms` tumor that had been treated at the Yonsei University College of Medicine from Jan. 1970 to Jul. 1998. With regard to treatment, radical nephrectomy combined with radiotherapy and chemotherapy was performed according to protocol. In recurred group, we used cyclophosphamide, VP-16, cis-platinum, ifosfamide.Results: Following the NWTS-III, there were I 21, II 10, III 12, IV 7 and V 3 with stages. There were 43(81.1%) favorable and 10(18.9%) unfavorable type. Recurrence rates were I 14.2.%, II 40.0%, III 25.0%, IV 42.8%, V 33.3% with stages, favorable 11.6%, unfavorable 90% with histologic features. The survival rates for those with stage were I 100%, II 64.3%, III 91.7%, IV 80.0%, V 66.7%. The survival rates for those with favorable and unfavorable histologic features were 96.2% and 68.6%. There was no difference in survival and recurrence rate according to age, symptoms and preoperative chemotherapy. In recurred cases, no specific chemotherapeutic agent increased the survival rate of Wilms` tumor significantly. Conclusions: The stage and histopathologic finding were important in the prognosis of Wilms` tumor, and no specific chemotherapeutic agent showed to increase the survival rate significantly in recurred cases.