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상피세포가 기관지 수축제에 대한 기니픽 기관 평활근 장력에 미치는 역할

Other Titles
 Epithelial modulation Guinea pig tracheal smooth muscle tension to contractile agents 
Authors
 구본녀  ;  고신옥  ;  김원옥  ;  김기준  ;  남용택  ;  서문석  ;  김승준 
Citation
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.38(5) : 920-926, 2000 
Journal Title
Journal of Korean Society of Anesthesiologist(대한마취과학회지)
ISSN
 0302-5780 
Issue Date
2000
Keywords
Airway ; trachea ; tracheal epithelium ; tracheal smooth muscle tension ; Animal: guinea- pig
Abstract
BACKGROUND
Asthma can be described as the hypersensitivity of the airway to various stimuli. Injury to tracheal epithelial cells could be the reason for tracheal hypersensitivity in asthma or upper respiratory infection. This study is based on the hypothesis that the dysfunction of the airway in asthma is caused by epithelial cell injury.
METHODS
After isolating guinea-pig tracheal preparations, in order to examine the role of airway epithelium in response to smooth muscle, we measured the contractile responses to acetylcholine, carbachol, and histamine on the isolated epithelium-denuded or epithelium-intact guinea-pig tracheal preparations. When tracheal tones were stabilized, each contractile agent was added cumulatively to the organ baths to obtain concentration-response curves, and ED50 and ED95 were calculated.
RESULTS
In both groups, tracheal tones increased in response to contractile agents, in concentration- dependent manners. In comparing both groups, the contractility of denuded trachea was increased by 10 7 and 10 6 M in acetylcholine, and by 10 6 M in histamine significantly. In denuded trachea, ED50 and ED95 increased significantly in response to both acetylcholine and histamine. However, they did not increase in carbachol.
CONCLUSIONS
The removal of the epithelium increased the contractile responses to acetylcholine and histamine.
Files in This Item:
T200001504.pdf Download
DOI
10.4097/kjae.2000.38.5.920
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Shin Ok(고신옥)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172058
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