상부위장관 증상이 없는 한국인에서 Helicobacter pylori 감염의 혈청학적 유병률에 관한 전국적 역학조사

Abstract

Background : Helicobacter pylori infection occurs throughout the world and causes various gastroduodenal diseases in all age groups. The prevalence of H. pylori infection varies among countries and races. The aim of this study was to evaluate the seroprevalence of H.pylori infectionin healthy people in Korea. Methods : From March 1998 to October 1998, 5,732 asymptomatic subjects responded to the self-assessment questionnaires from 54hospitals were enrolled. Serum level of anti- H.pylori IgG was measured by ELISA test. Results : The overall prevalence of H. pylori infection was 46.6% and showed no significant difference between male (47.2%) and female (45.9%). According to the geographic areas, the highly prevalent provinces were Kangwon (53.4%), Cheju (52.9%) and Jeonra provinces (50.6%), while Seoul (41.9%) was the lowest prevalent area. The seroprevalence increased with age and was the highest at 40' s (78.5%). The characteristic feature of this study was that the infection rate increased steeply in three age groups (10- 12, 16- 19 years old and 30' s). In Seoul, there was no different prevalence rate among the districts studied. Conclusion : The nation- wide seroprevalence of H. pylori infection in Korea is higher than that of the developed countries. We hope that this study provides the landmark for the study of H. pylori infection in Korea.(Korean J Med 59:388- 397, 2000)