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신이식후 당뇨병의 발병원인에 있어서 인슐린 분비능과 저항성의 역할
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.date.accessioned | 2019-11-11T05:33:38Z | - |
dc.date.available | 2019-11-11T05:33:38Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 1015-6461 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171974 | - |
dc.description.abstract | Background : Our study was undertaken to investigate the pathogenesis and possible risk factors for post -renaltransplantation diabetes mellitus (PTDM). Methods : we recruited 114patients with normal glucoset olerance , and performed the 75g oral glucose tolerance tests (OGTT) and the short insulin tolerance tests 1week before and 9∼12 months after transplantation , respectively . Results : The subjects were classified into three group son the basis of OGTT after transplantation by WHO criteria : 1) 36 (3 1.6%) subjects with normal glucose tolerance ; 2) 51 (45 .7%) subjects with impaired glucose tolerance ; and 3) 27 (23 .7%) subjects with post-renal transplantation diabete smellitus. Dosages of steroid and cyclosporin-A (C sA) were equivalent among the 3groups . Before transplantation , the fast ingand 2-h plasmaglucose , and proinsulin / insulin (PI/ I) ratios were significantly higher in the IGT and PTDM group sthan in the NGT group , but insulin sensitivity index (ISI) was not different among 3groups. In addition, the are a under the curve (AUC ) -insulinon OGTT was significantly lower in the PTDM group than in the NGT group. After transplantation , however, ISI was increased in all groups. Furthermore, the ISI and PI/I ratios revealed significantly higher values in the PTDM group than in the NGT group after transplantation. Conclusion : These results revealed that fast in gand 2-h plasm aglucoselevels, as well asproinsulin/ insulin ratio before transplantation, which may all be in dicators of -cell dysfunction, could be the predic to rsforthe development of PTDM and -cell dysfunction rather than insulin resistance was proved to be the mainfactor for the pathogenes is o f PTDM (J Kor Diabete s Asso 485∼ 496, 2000) | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | Korean | - |
dc.publisher | 대한당뇨병학회 | - |
dc.relation.isPartOf | Journal of Korean Diabetes Association (당뇨병) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 신이식후 당뇨병의 발병원인에 있어서 인슐린 분비능과 저항성의 역할 | - |
dc.title.alternative | The Role of β-cell Dysfunction and Insulin Resistance in the Development of Post - renal Transplantation Diabetes Mellitus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 남재현 | - |
dc.contributor.googleauthor | 이현철 | - |
dc.contributor.googleauthor | 안철우 | - |
dc.contributor.googleauthor | 문장일 | - |
dc.contributor.googleauthor | 김순일 | - |
dc.contributor.googleauthor | 박기일 | - |
dc.contributor.googleauthor | 송영득 | - |
dc.contributor.googleauthor | 임승길 | - |
dc.contributor.googleauthor | 김경래 | - |
dc.contributor.googleauthor | 허갑범 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.relation.journalcode | J01508 | - |
dc.identifier.url | http://kiss.kstudy.com/thesis/thesis-view.asp?key=1921526 | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | 안철우 | - |
dc.contributor.affiliatedAuthor | 이현철 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 485 | - |
dc.citation.endPage | 491 | - |
dc.identifier.bibliographicCitation | Journal of Korean Diabetes Association (당뇨병), Vol.25(4) : 485-491, 2000 | - |
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