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The prediction of adverse pregnancy outcome using low unconjugated estriol in the second trimester of pregnancy without risk of Down's syndrome.

DC Field Value Language
dc.contributor.author김세광-
dc.date.accessioned2019-11-11T05:30:15Z-
dc.date.available2019-11-11T05:30:15Z-
dc.date.issued2000-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171929-
dc.description.abstractTo investigate the relationship between low unconjugated estriol (uE3) levels in the second trimester and adverse perinatal outcomes in pregnancies without increased risk for Down's syndrome, 1,096 women under 35 years of age underwent a mid-trimester AFP-hCG-uE3 screening test between January 1995 and June 1998. Multiple pregnancies, maternal diabetes, smoking and elevation of AFP and hCG levels more than 2.0 multiple of median (MoM) were excluded from our study population. The results were divided into a low-uE3 group with uE3 levels at or below 0.75 MoM and a normal uE3 group with uE3 levels above 0.75 MoM. The risk for adverse pregnancy outcome was compared between the two groups and the role of low uE3 as a predictor of adverse pregnancy outcome was determined. The data were assessed using chi 2 or Fisher exact test and then logistic regression was used for the final analysis. The odds ratio (OR) and corresponding 95% confidence intervals (CI) were also calculated. Unconjugated E3 levels at or below 0.75 MoM was significantly associated with fetal growth restriction after adjustment for maternal age, weight, sampling weeks, AFP and hCG levels (OR 0.413, 95% CI 0.174-0.900; P = 0.035). Low uE3 levels in the second-trimester could help in the detection of fetal growth restriction by a low risk group in Down's syndrome. Careful gestational dating and serial clinical and sonographic assessment of fetal growth may be required for the clinician to manage these parturients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHChorionic Gonadotropin/blood-
dc.subject.MESHDown Syndrome/diagnosis-
dc.subject.MESHEstriol/blood*-
dc.subject.MESHFemale-
dc.subject.MESHFetal Growth Retardation/diagnosis*-
dc.subject.MESHHumans-
dc.subject.MESHPregnancy-
dc.subject.MESHPregnancy Trimester, Second-
dc.subject.MESHRisk-
dc.subject.MESHalpha-Fetoproteins/analysis-
dc.titleThe prediction of adverse pregnancy outcome using low unconjugated estriol in the second trimester of pregnancy without risk of Down's syndrome.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorSuk Young Kim-
dc.contributor.googleauthorSei Kwang Kim-
dc.contributor.googleauthorJi sung Lee-
dc.contributor.googleauthorIn Kyu Kim-
dc.contributor.googleauthorKook Lee-
dc.identifier.doi10.3349/ymj.2000.41.2.226-
dc.contributor.localIdA00601-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid10817024-
dc.subject.keywordUnconjugated estriol-
dc.subject.keywordfetal growth-
dc.subject.keywordpregnancy outcome-
dc.subject.keywordsecond-trimester-
dc.subject.keywordscreening program-
dc.contributor.alternativeNameKim, Sei Kwang-
dc.contributor.affiliatedAuthor김세광-
dc.citation.volume41-
dc.citation.number2-
dc.citation.startPage226-
dc.citation.endPage229-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.41(2) : 226-229, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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