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Tissue plasminogen activator and plasminogen activator inhibitor-1 in human choledochal bile
DC Field | Value | Language |
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dc.contributor.author | 이관식 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2019-11-11T05:29:51Z | - |
dc.date.available | 2019-11-11T05:29:51Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171923 | - |
dc.description.abstract | Fibrinolytic properties have been detected in animal and human gallbladder (GB) bile. Plasminogen activator inhibitor-1 (PAI-1) has been reported in greater concentration in GB stone bile and may be a nucleating factor in the pathogenesis of GB stone formation. It is unknown whether or not human choledochal bile has similar properties, which could have a role in choledocholithiasis. The aims of this study were to determine the presence of fibrinolytic properties of human choledochal bile and to compare those properties among normal, acalculous, and calculous-infected choledochal bile. Tissue plasminogen activator (t-PA) and PAI-1 of choledochal bile were measured by enzyme linked immunosorbent assay in patients with cholangitis due to acalculous bile duct obstructions (n = 9), choledocholithiasis with cholangitis (n = 20), and normal bile (n = 7). The t-PA concentration of choledochal bile was no different among the three groups (acalculous-infected bile, median 4.61 ng/ml, and calculous-infected bile, 4.61 ng/ml, versus normal bile, 7.33 ng/ml). PAI-1 was detected in choledochal bile in significantly greater concentrations in patients with acalculous cholangitis due to bile duct obstructions and choledocholithiasis with cholangitis (acalculous-infected bile, median 0.36 ng/ml, and calculous-infected bile, 0.1 ng/ml, versus normal bile, 0.02 ng/ml, p < 0.05), but the bile concentration of PAI-1 was no different between the acalculous and calculous-infected choledochal bile. Human choledochal bile possesses t-PA and PAI-1. PAI-1 was present in greater concentrations in both acalculous and calculous-infected choledochal bile. Increased levels of PAI-1 may be an epiphenomenon of cholangitis rather than a factor in the pathogenesis of choledocholithiasis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | Yonsei Medical Journal | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bile/chemistry* | - |
dc.subject.MESH | Bile/microbiology | - |
dc.subject.MESH | Cholangitis/chemically induced | - |
dc.subject.MESH | Cholangitis/etiology | - |
dc.subject.MESH | Cholangitis/metabolism | - |
dc.subject.MESH | Cholangitis/microbiology | - |
dc.subject.MESH | Cholestasis/complications | - |
dc.subject.MESH | Cholestasis/metabolism | - |
dc.subject.MESH | Common Bile Duct/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gallstones/complications | - |
dc.subject.MESH | Gallstones/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Plasminogen Activator Inhibitor 1/analysis* | - |
dc.subject.MESH | Tissue Plasminogen Activator/analysis* | - |
dc.title | Tissue plasminogen activator and plasminogen activator inhibitor-1 in human choledochal bile | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Se-Joon Lee | - |
dc.contributor.googleauthor | Jun-Sik Cho | - |
dc.contributor.googleauthor | Jun-Pyo Chung | - |
dc.contributor.googleauthor | Kwan-Sik Lee | - |
dc.contributor.googleauthor | Jae-Bock Chung | - |
dc.contributor.googleauthor | Sang-In Lee | - |
dc.contributor.googleauthor | Young-Myoung Moon | - |
dc.contributor.googleauthor | Jin-Kyung Kang | - |
dc.contributor.googleauthor | Sung-Won Kwon | - |
dc.contributor.googleauthor | Hoon-Sang Chi | - |
dc.contributor.googleauthor | Jong-Rak Choi | - |
dc.contributor.googleauthor | Kyung-Soon Song | - |
dc.identifier.doi | 10.3349/ymj.2000.41.1.119 | - |
dc.contributor.localId | A02666 | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 10731929 | - |
dc.subject.keyword | Fibrinolysis | - |
dc.subject.keyword | Biliary Tract | - |
dc.subject.keyword | Choledocholithiasis | - |
dc.contributor.alternativeName | Lee, Kwan Sik | - |
dc.contributor.affiliatedAuthor | 이관식 | - |
dc.contributor.affiliatedAuthor | 최종락 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 119 | - |
dc.citation.endPage | 122 | - |
dc.identifier.bibliographicCitation | Yonsei Medical Journal, Vol.41(1) : 119-122, 2000 | - |
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