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Expression of leptin receptor in human atherosclerotic lesions : potential role in intimal neovascularization

DC Field Value Language
dc.contributor.author강석민-
dc.contributor.author권혁문-
dc.date.accessioned2019-11-11T05:29:46Z-
dc.date.available2019-11-11T05:29:46Z-
dc.date.issued2000-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171922-
dc.description.abstractNeovascularization of the adventitial vasa vasorum with extension into the intima of atherosclerotic lesions is frequently observed, but its pathophysiological significance is still subject to debate. Recently, leptin, the product of the Ob gene, was identified. Leptin, via activation of the endothelial receptor (Ob-R), generates a growth signal involving a tyrosine kinase-dependent intracellular pathway and promotes angiogenic processes. We hypothesized that a high concentration of leptin within vasa vasorum and plaque itself, may influence inflammatory and vascular neovascularization coupling with functional upregulation of the vascular endothelial growth factor (VEGF). Microscopic computerized tomography was utilized for the spatial distribution of vasa vasorum and intimal neovascularization from atherosclerotic human coronary arteries. Atherosclerotic coronary arteries showed a dense plexus of microvessels in the adventitia and plaque itself. Microscopic analysis from human atherosclerotic aortas revealed an increase in the intimal thickness with neovascularization. The immunoreactivity for Ob-R, VEGF and matrix metalloproteinase (MMP) increased in atherosclerotic plaque, predominantly in the endothelial lining of the intimal neovessel and macrophages/foam cells. Our observation of a prominent colocalization between Ob-R, VEGF and MMP supports this hypothesis and these factors participate in the neovascularization of atherosclerotic lesions. The present study is the first report on vascular tissue and it opens a promising perspective concerning future investigations of leptin-dependent modulation of atherogenesis and vascular neovascularization under pathophysiolgical conditions.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHArteriosclerosis/metabolism*-
dc.subject.MESHArteriosclerosis/pathology-
dc.subject.MESHArteriosclerosis/physiopathology-
dc.subject.MESHBlood Vessels/metabolism-
dc.subject.MESHBlood Vessels/pathology-
dc.subject.MESHCarrier Proteins/metabolism*-
dc.subject.MESHCarrier Proteins/physiology-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeovascularization, Pathologic/physiopathology-
dc.subject.MESHReceptors, Cell Surface*-
dc.subject.MESHReceptors, Leptin-
dc.titleExpression of leptin receptor in human atherosclerotic lesions : potential role in intimal neovascularization-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorHyuck Moon Kwon-
dc.contributor.googleauthorBum kee Hong-
dc.contributor.googleauthorDongsoo Kim-
dc.contributor.googleauthorIn Jai Kim-
dc.contributor.googleauthorEui Young choi-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorHyun-Seung Kim-
dc.contributor.googleauthorMyung Sin Kim-
dc.contributor.googleauthorHyuck Chan Kwon-
dc.identifier.doi10.3349/ymj.2000.41.1.68-
dc.contributor.localIdA00037-
dc.contributor.localIdA00260-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid10731922-
dc.subject.keywordLeptin receptor-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordNeovascularization-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.contributor.affiliatedAuthor권혁문-
dc.citation.volume41-
dc.citation.number1-
dc.citation.startPage68-
dc.citation.endPage75-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.41(1) : 68-75, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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