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Adrenergic sensitivity of uninjured C-fiber nociceptors in neuropathic rats

DC Field Value Language
dc.contributor.author남택상-
dc.contributor.author임중우-
dc.date.accessioned2019-11-11T05:28:24Z-
dc.date.available2019-11-11T05:28:24Z-
dc.date.issued2000-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171907-
dc.description.abstractWe investigated the adrenergic sensitivity of afferent fibers in the L4 dorsal roots of rats with a unilateral ligation of the L5-L6 spinal nerves. About 12% of nociceptive fibers on the affected side were excited by sympathetic stimulation or by intra-arterial injection of norepinephrine which did not affect A beta-fiber activity. Sympathetic excitation of nociceptive fibers was suppressed by alpha 1-antagonist prazosin, while it was unaffected by alpha 2-antagonist yohimbine. Most of these fibers were excited by intra-arterial injection of alpha 1-agonist phenylephrine, without being affected by an injection of alpha 2-agonist clonidine. Sympathetic excitation was blocked by lidocaine applied near the receptive fields of recorded fibers. The results suggested that some nociceptors remaining intact after partial nerve injury become sensitive to sympathetic activity by the mediation of alpha 1-adrenoceptors in the peripheral endings.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHMale-
dc.subject.MESHNerve Fibers/physiology*-
dc.subject.MESHNociceptors/physiology*-
dc.subject.MESHNorepinephrine/pharmacology-
dc.subject.MESHPain/physiopathology*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptors, Adrenergic, alpha-1/physiology*-
dc.titleAdrenergic sensitivity of uninjured C-fiber nociceptors in neuropathic rats-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학교실)-
dc.contributor.googleauthorTaick Sang Nam-
dc.contributor.googleauthorDong Soo Yeon-
dc.contributor.googleauthorJoong Woo Leem-
dc.contributor.googleauthorKwang Se paik-
dc.identifier.doi10.3349/ymj.2000.41.2.252-
dc.contributor.localIdA01271-
dc.contributor.localIdA03409-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid10817027-
dc.subject.keywordPeripheral Nerve Injury-
dc.subject.keywordNeuropathy-
dc.subject.keywordCausalgia-
dc.subject.keywordNociceptor-
dc.subject.keywordAlpha-1 Adrenoceptor-
dc.contributor.alternativeNameNam, Taick Sang-
dc.contributor.affiliatedAuthor남택상-
dc.contributor.affiliatedAuthor임중우-
dc.citation.volume41-
dc.citation.number2-
dc.citation.startPage252-
dc.citation.endPage257-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.41(2) : 252-257, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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