Cited 5 times in
An overview of cartilage tissue engineering
DC Field | Value | Language |
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dc.contributor.author | 김현우 | - |
dc.date.accessioned | 2019-11-11T05:27:56Z | - |
dc.date.available | 2019-11-11T05:27:56Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171900 | - |
dc.description.abstract | Articular cartilage regeneration refers to the formation of new tissue that is indistinguishable from the native articular cartilage with respect to zonal organization, biochemical composition, and mechanical properties. Due to a limited capacity to repair cartilage, scar tissue frequently has a poorly organized structure and lacks the functional characteristics of normal cartilage. The degree of success to date achieved using a purely cell- or biological-based approach has been modest. Potentially the development of a hybrid strategy, whereby, chondrocytes or chondrogenic stem cells are combined with a matrix, making cartilage in vitro, which is then subsequently transplanted, offers a route towards a new successful treatment modality. The success of this approach depends upon the material being biocompatible, processable into a suitable three-dimensional structure and eventually biodegradable without harmful effects. In addition, the material should have a sufficient porosity to facilitate high cell loading and tissue ingrowth, and it should be able to support cell proliferation, differentiation, and function. The cell-polymer-bioreactor system provides a basis for studying the structural and functional properties of the cartilaginous matrix during its development, because tissue concentrations of glycosaminoglycan and collagen can be modulated by altering the conditions of tissue cultivation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | Yonsei Medical Journal | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biomedical Engineering* | - |
dc.subject.MESH | Bioreactors | - |
dc.subject.MESH | Cartilage*/growth & development | - |
dc.subject.MESH | Extracellular Matrix/physiology | - |
dc.subject.MESH | Humans | - |
dc.title | An overview of cartilage tissue engineering | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학교실) | - |
dc.contributor.googleauthor | Hyun Woo Kim | - |
dc.contributor.googleauthor | Chang Dong Han | - |
dc.identifier.doi | 10.3349/ymj.2000.41.6.766 | - |
dc.contributor.localId | A01124 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 11204827 | - |
dc.subject.keyword | Cartilage | - |
dc.subject.keyword | tissue engineering | - |
dc.contributor.alternativeName | Kim, Hyun Woo | - |
dc.contributor.affiliatedAuthor | 김현우 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 766 | - |
dc.citation.endPage | 773 | - |
dc.identifier.bibliographicCitation | Yonsei Medical Journal, Vol.41(6) : 766-773, 2000 | - |
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