Cited 18 times in
Conduction block by clonidine is not mediated by alpha2-adrenergic receptors in rat sciatic nerve fibers.
DC Field | Value | Language |
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dc.contributor.author | 임중우 | - |
dc.date.accessioned | 2019-11-11T05:24:30Z | - |
dc.date.available | 2019-11-11T05:24:30Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 1098-7339 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171854 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVES: Clonidine, an alpha(2)-adrenergic agonist, has been shown to prolong local anesthesia. It appears that clonidine by itself produces conduction block by acting on peripheral nerves. However, whether clonidine-induced conduction block is mediated through alpha(2)-adrenergic receptors remains unclear. The purpose of this study was to see if clonidine's nerve-blocking action was through alpha(2)-adrenergic receptors by examining clonidine's action in the presence of alpha(2)-adrenergic antagonists. METHODS: The compound action potentials (CAPs) evoked by electrical stimuli were recorded from the isolated rat sciatic nerve in a recording chamber. Conduction block was examined by analyzing CAPs with regard to peak amplitude and time-to-peak in the presence of clonidine alone or clonidine plus alpha(2)-adrenergic antagonist yohimbine or idazoxan. RESULTS: Both clonidine and yohimbine produced concentration-dependent, reversible, conduction block. Based on concentration-response relationships, the 50% of effective concentration (EC(50)) were estimated to be 1.61 +/- 0.51 mmol/L (mean +/- SD) for clonidine and 51.4 +/- 27.2 micromol/L for yohimbine. A mixture of equal volumes of 2.07 mmol/L clonidine and 55.6 micromol/L yohimbine produced conduction block to a level close to the mean value between conduction blocks induced by 2.07 mmol/L clonidine alone and 55.6 micromol/L yohimbine alone. Addition of idazoxan, a more specific alpha(2)-adrenergic antagonist than yohimbine, to clonidine was without effect on clonidine-induced conduction block. CONCLUSIONS: The results indicated that the mixture of clonidine and yohimbine, in which either drug inhibited impulse conduction, produced conduction block in an additive manner, and that clonidine-induced conduction block was not reversed by coapplication with a specific alpha(2)-adrenergic antagonist idazoxan. These data suggest that clonidine's effects likely depend on mechanisms not mediated by alpha(2)-adrenergic receptors. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | Regional Anesthesia and Pain Medicine | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adrenergic alpha-Agonists/pharmacology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Clonidine/pharmacology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neural Conduction/drug effects* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptors, Adrenergic, alpha-2/drug effects* | - |
dc.subject.MESH | Receptors, Adrenergic, alpha-2/physiology | - |
dc.subject.MESH | Sciatic Nerve/drug effects* | - |
dc.subject.MESH | Sciatic Nerve/physiology | - |
dc.subject.MESH | Yohimbine/pharmacology | - |
dc.title | Conduction block by clonidine is not mediated by alpha2-adrenergic receptors in rat sciatic nerve fibers. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.googleauthor | Joong Woo Leem | - |
dc.contributor.googleauthor | Yoon Choi | - |
dc.contributor.googleauthor | Song Min Han | - |
dc.contributor.googleauthor | Mi Ja Yoon | - |
dc.contributor.googleauthor | Ji Yeon Sim | - |
dc.contributor.googleauthor | Seung Woon Leem | - |
dc.identifier.doi | 10.1053/rapm.2000.16160 | - |
dc.contributor.localId | A03409 | - |
dc.relation.journalcode | J02601 | - |
dc.identifier.eissn | 1532-8651 | - |
dc.identifier.pmid | 11097671 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1098733900412277 | - |
dc.subject.keyword | Clonidine | - |
dc.subject.keyword | Compound action potential | - |
dc.subject.keyword | Peripheral nerve block | - |
dc.subject.keyword | Adrenergic receptor | - |
dc.subject.keyword | Yohimbine | - |
dc.subject.keyword | Idazoxan | - |
dc.contributor.alternativeName | Leem, Joong Woo | - |
dc.contributor.affiliatedAuthor | 임중우 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 620 | - |
dc.citation.endPage | 625 | - |
dc.identifier.bibliographicCitation | Regional Anesthesia and Pain Medicine, Vol.25(6) : 620-625, 2000 | - |
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