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Transient induction of neuronal nitric oxide synthase in neurons of rat cerebral cortex after status epilepticus

DC Field Value Language
dc.contributor.author허경-
dc.date.accessioned2019-11-11T05:22:30Z-
dc.date.available2019-11-11T05:22:30Z-
dc.date.issued2000-
dc.identifier.issn0304-3940-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171820-
dc.description.abstractThe change in neuronal nitric oxide synthase (nNOS) expression after status epilepticus induced by kainate was examined in the rat cerebral cortex. Expressional change was assessed using nNOS immunohistochemistry and reverse transcription-polymerase chain reaction for nNOS mRNA. Constitutive nNOS-positive neurons was observed in the cerebral cortex of the control group. At 1 and 3 days after status epilepticus, nNOS-positive neurons were present in a deep layer of various cortical regions such as primary motor cortex, secondary motor cortex, primary somatosensory cortex, secondary somatosensory cortex, parietal association cortex, insular cortex, ectorhinal cortex, temporal association cortex, auditory cortex and visual cortex. The level of nNOS mRNA increased at 1, 3, 6 and 12 days after status epilepticus compared to controls. This report provides the first morphological evidence that nNOS are induced in neurons of the cerebral cortex following seizure.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Scientific Publishers Ireland-
dc.relation.isPartOfNeuroscience Letters-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHCell Count-
dc.subject.MESHCerebral Cortex/cytology-
dc.subject.MESHCerebral Cortex/enzymology*-
dc.subject.MESHGene Expression Regulation, Enzymologic-
dc.subject.MESHMale-
dc.subject.MESHNeurons/enzymology*-
dc.subject.MESHNitric Oxide Synthase/genetics*-
dc.subject.MESHNitric Oxide Synthase Type I-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Inbred F344-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHStatus Epilepticus/physiopathology*-
dc.titleTransient induction of neuronal nitric oxide synthase in neurons of rat cerebral cortex after status epilepticus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorYoungbuhm Huh-
dc.contributor.googleauthorKyoung Heo-
dc.contributor.googleauthorChan Park-
dc.contributor.googleauthorHeekyung Ahn-
dc.identifier.doi10.1016/S0304-3940(00)00800-4-
dc.contributor.localIdA04341-
dc.relation.journalcodeJ02364-
dc.identifier.eissn1872-7972-
dc.identifier.pmid10686413-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0304394000008004-
dc.subject.keywordInduction-
dc.subject.keywordNeuronal nitric oxide synthase-
dc.subject.keywordCerebral cortex-
dc.subject.keywordKainate-
dc.subject.keywordStatus epilepticus-
dc.contributor.alternativeNameHeo, Kyoung-
dc.contributor.affiliatedAuthor허경-
dc.citation.volume281-
dc.citation.number1-
dc.citation.startPage49-
dc.citation.endPage52-
dc.identifier.bibliographicCitationNeuroscience Letters, Vol.281(1) : 49-52, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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