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Adaptive responses is differently induced depending on the sensitivity to radiation induced cell death in mouse epidermal cells

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dc.contributor.author이윤실-
dc.date.accessioned2019-11-11T05:15:54Z-
dc.date.available2019-11-11T05:15:54Z-
dc.date.issued2000-
dc.identifier.issn0742-2091-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171738-
dc.description.abstractWe investigated the relationship between induction of radio-adaptive response and cell death in mouse normal and neoplastic epidermal cells. Mouse normal primary keratinocytes (PK), cancer-prone cells [v-rasHa-transfected mouse keratinocytes (ras-PK), and line 308 cells (mouse skin papilloma cells which have activated rasHa gene with A-to-T transversion at codon 61) were primed with a low dose of gamma-rays (0.01 Gy), and were challenged with a high dose (4 Gy) after a 4 or 7 h interval. The induction of cell death in PK was 2-10 times higher and was also more rapid in PK than in ras-PK or 308 cells. Low-dose pretreatment with a 4 h interval decreased cell death, and this adaptive response was prominent in PK, whereas it was less obvious in the cases of ras-PK and 308 cells. The response of each protein kinase C (PKC) isozymes to high-dose radiation, especially PKCalpha, PKCdelta, PKCepsilon, and PKCeta, were different between the normal and ras oncogene-activated neoplastic keratinocytes; translocation of these isozymes to membrane occurred more rapidly in normal than in neoplastic cells. Furthermore, low-dose pretreatment did not induce the translocation of PKCdelta in PK significantly more than in ras-PK and 308. Thus, the difference in the induction of radio-adaptive responses between mouse normal and neoplastic epidermal cells reflects difference in the rapidity of cell death, and responsiveness of PKC may affect this adaptive response.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherKluwer Academic Publishers-
dc.relation.isPartOfCell Biology and Toxicology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdaptation, Physiological/radiation effects-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/radiation effects*-
dc.subject.MESHCell Line, Transformed-
dc.subject.MESHCytosol/enzymology-
dc.subject.MESHEpidermal Cells*-
dc.subject.MESHEpidermis/radiation effects*-
dc.subject.MESHIn Situ Nick-End Labeling-
dc.subject.MESHIsoenzymes/metabolism-
dc.subject.MESHKeratinocytes/cytology*-
dc.subject.MESHKeratinocytes/enzymology-
dc.subject.MESHKeratinocytes/radiation effects*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHPapilloma-
dc.subject.MESHProtein Kinase C/metabolism-
dc.subject.MESHProtein Kinase C-alpha-
dc.subject.MESHRadiation Dosage-
dc.subject.MESHRadiation Injuries/metabolism-
dc.subject.MESHSkin Neoplasms-
dc.subject.MESHTumor Cells, Cultured-
dc.subject.MESHras Proteins/metabolism-
dc.titleAdaptive responses is differently induced depending on the sensitivity to radiation induced cell death in mouse epidermal cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorS.J. Lee-
dc.contributor.googleauthorS.A. Choi-
dc.contributor.googleauthorC.K. Cho-
dc.contributor.googleauthorT.H. Kim-
dc.contributor.googleauthorK.S. Jeong-
dc.contributor.googleauthorS.Y.Yoo-
dc.contributor.googleauthorY.S. Lee-
dc.identifier.doi10.1023/a:1007658905639-
dc.contributor.localIdA03021-
dc.relation.journalcodeJ00476-
dc.identifier.eissn1573-6822-
dc.identifier.pmid11032361-
dc.identifier.urlhttps://link.springer.com/article/10.1023/A:1007658905639-
dc.subject.keywordadaptive response-
dc.subject.keywordnormal cells-
dc.subject.keywordneoplastic cells-
dc.subject.keywordprotein kinase C-
dc.subject.keywordcell death-
dc.contributor.alternativeNameLee, Yun Sil-
dc.contributor.affiliatedAuthor이윤실-
dc.citation.volume16-
dc.citation.number3-
dc.citation.startPage175-
dc.citation.endPage184-
dc.identifier.bibliographicCitationCell Biology and Toxicology, Vol.16(3) : 175-184, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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