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Correlation of tissue and blood plasminogen activation system in breast cancer

 Sun Young Rha  ;  Woo Ick Yang  ;  Soo Jung Gong  ;  Jin Ju Kim  ;  Nae Choon Yoo  ;  Jae Kyung Roh  ;  Jin Sik Min  ;  Kyong Sik Lee  ;  Byung Soo Kim  ;  Hyun Cheol Chung 
 Journal of Neurology, Neurosurgery and Psychiatry, Vol.150(2) : 137-145, 2000 
Journal Title
 Journal of Neurology, Neurosurgery and Psychiatry 
Issue Date
Adult ; Aged ; Breast Neoplasms/metabolism* ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Middle Aged ; Plasminogen Activator Inhibitor 1/analysis* ; Receptors, Cell Surface/analysis* ; Receptors, Urokinase Plasminogen Activator ; Survival Rate ; Urokinase-Type Plasminogen Activator/metabolism*
Tissue ; Blood ; uPA ; PAI-1 ; uPAR ; Breast cancer
The plasminogen activation system plays a crucial role during cancer invasion and metastasis. In the solid tumor, urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor type-1 (PAI-1) and uPA receptor (uPAR) are considered as prognostic factors. In this study, we have investigated whether secretion of the uPA, PAI-1 and uPAR from the primary breast cancer tissue can be detected in the blood of the patients using the ELISA assay. We have found that the plasminogen activation system (uPA, PAI-1, uPAR) of tumor tissue is activated from the early stage of breast cancer. However, only a number of metastatic lymph nodes was a prognostic factor in multivariate analysis for relapse. The blood level of the plasminogen activation system correlated with that of tissue in an order of uPAR (r(2)=0.61; P=0.001), uPA (r(2)=0.35; P=0.001) and PAI-1 (r(2)=0.11; P=0.001). We conclude that the total uPAR level of cancer tissue can be substituted by that which is detected in the blood for further clinical applications.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
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