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Involvement of oxidative stress and caspase-3 in cortical infarction after photothrombotic ischemia in mice.

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dc.contributor.author김경환-
dc.date.accessioned2019-11-11T05:11:24Z-
dc.date.available2019-11-11T05:11:24Z-
dc.date.issued2000-
dc.identifier.issn0271-678X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171684-
dc.description.abstractApoptosis-related cell death is linked to oxidative stress and caspases in experimental cerebral ischemia, However, the role of oxidative stress in caspase activation and subsequent apoptotic cell death after cerebral ischemia is unknown, The authors evaluated the role of oxidative stress in ischemic cerebral infarction after photothrombosis and the relation between oxidative stress and caspase-related cell death 6 and 24 hours after ischemia with and without U-74389G, a potent free radical scavenger (10 mg/kg, 30 minutes before and after ischemia induction). Reactive oxygen species, detected by hydroethidine oxidation, and cytosolic cytochrome c were detected in early ischemic lesions. Western blot analysis showed the cleaved form and the level of the proform of caspase-3 in the ischemic lesion 24 hours after ischemia. Decreased caspase-3 immunoreactivity was detected in the antioxidant-treated group after ischemia. Decreased DNA fragmentation and laddering were detected and the lesion was smaller in the treated group after ischemia compared with the untreated group. Oxidative stress and cytochrome c release occur in the ischemic lesion after photothrombotic ischemia. The free radical scavenger attenuated caspase-3 up-regulation, DNA fragmentation, and the final lesion. The authors concluded that oxidative stress may mediate caspase-related apoptotic cell death and subsequent cortical infarction after photothrombotic ischemia.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSAGE Publications-
dc.relation.isPartOfJournal of Cerebral Blood Flow and Metabolism-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHAntibodies-
dc.subject.MESHAntioxidants/pharmacology-
dc.subject.MESHBlood-Brain Barrier/physiology-
dc.subject.MESHBlotting, Western-
dc.subject.MESHBrain Ischemia/drug therapy-
dc.subject.MESHBrain Ischemia/metabolism*-
dc.subject.MESHCaspase 3-
dc.subject.MESHCaspases/analysis-
dc.subject.MESHCaspases/immunology-
dc.subject.MESHCaspases/metabolism*-
dc.subject.MESHCerebral Cortex/blood supply-
dc.subject.MESHCerebral Cortex/metabolism-
dc.subject.MESHCerebral Infarction/drug therapy-
dc.subject.MESHCerebral Infarction/metabolism*-
dc.subject.MESHCerebrovascular Circulation/drug effects-
dc.subject.MESHCerebrovascular Circulation/physiology-
dc.subject.MESHCytochrome c Group/metabolism-
dc.subject.MESHCytosol/enzymology-
dc.subject.MESHDNA Fragmentation-
dc.subject.MESHFree Radical Scavengers/pharmacology-
dc.subject.MESHIn Situ Nick-End Labeling-
dc.subject.MESHIntracranial Thrombosis/drug therapy-
dc.subject.MESHIntracranial Thrombosis/metabolism*-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred Strains-
dc.subject.MESHOxidative Stress/drug effects-
dc.subject.MESHOxidative Stress/physiology*-
dc.subject.MESHPregnatrienes/pharmacology-
dc.titleInvolvement of oxidative stress and caspase-3 in cortical infarction after photothrombotic ischemia in mice.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorGyung W. Kim-
dc.contributor.googleauthorTaku Sugawara-
dc.contributor.googleauthorPak H. Chan-
dc.identifier.doi10.1097/00004647-200012000-00008-
dc.contributor.localIdA00310-
dc.relation.journalcodeJ01306-
dc.identifier.eissn1559-7016-
dc.identifier.pmid11129785-
dc.identifier.urlhttp://journals.sagepub.com/doi/abs/10.1097/00004647-200012000-00008-
dc.subject.keywordOxidative stress-
dc.subject.keywordPhotothrombotic ischemia-
dc.subject.keywordCaspase-3-
dc.subject.keywordDNA fragmentation-
dc.contributor.alternativeNameKim, Gyung Whan-
dc.contributor.affiliatedAuthor김경환-
dc.citation.volume20-
dc.citation.number12-
dc.citation.startPage1690-
dc.citation.endPage1701-
dc.identifier.bibliographicCitationJournal of Cerebral Blood Flow and Metabolism, Vol.20(12) : 1690-1701, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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