Cited 116 times in
Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid.
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.date.accessioned | 2019-11-11T05:11:21Z | - |
dc.date.available | 2019-11-11T05:11:21Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0271-678X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171683 | - |
dc.description.abstract | Excitotoxicity is implicated in the pathogenesis of several neurologic diseases, such as chronic neurodegenerative diseases and stroke. Recently, it was reported that excitotoxicity has a relationship to apoptotic neuronal death, and that the mitochondrial toxin, 3-nitropropionic acid (3-NP), could induce apoptosis in the striatum. Although striatal lesions produced by 3-NP could develop through an excitotoxic mechanism, the exact relationship between apoptosis induction and excitotoxicity after 3-NP treatment is still not clear. The authors investigated the role of excitotoxicity and oxidative stress on apoptosis induction within the striatum after intraperitoneal injection of 3-NP. The authors demonstrated that removal of the corticostriatal glutamate pathway reduced superoxide production and apoptosis induction in the denervated striatum of decorticated mice after 3-NP treatment. Also, the N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, prevented apoptosis in the striatum after 3-NP treatment for 5 days, whereas the non-NMDA receptor antagonist, 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline, was ineffective. The authors also evaluated the initial type of neuronal death by 3-NP treatment for different durations from 1 to 5 days. In early striatal damage, apoptotic neuronal death initially occurred after 3-NP treatment. Our data show that excitotoxicity related to oxidative stress initially induces apoptotic neuronal death in mouse striatum after treatment with 3-NP. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | SAGE Publications | - |
dc.relation.isPartOf | Journal of Cerebral Blood Flow and Metabolism | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/physiology* | - |
dc.subject.MESH | Caspases/metabolism | - |
dc.subject.MESH | Corpus Striatum/metabolism | - |
dc.subject.MESH | Corpus Striatum/pathology | - |
dc.subject.MESH | Corpus Striatum/physiopathology* | - |
dc.subject.MESH | Decerebrate State/metabolism | - |
dc.subject.MESH | Dizocilpine Maleate/pharmacology | - |
dc.subject.MESH | Excitatory Amino Acid Antagonists/pharmacology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mitochondria/drug effects | - |
dc.subject.MESH | Nervous System/drug effects | - |
dc.subject.MESH | Nervous System/physiopathology | - |
dc.subject.MESH | Neurotoxins/metabolism* | - |
dc.subject.MESH | Nitro Compounds | - |
dc.subject.MESH | Oxidative Stress/physiology* | - |
dc.subject.MESH | Propionates/pharmacology* | - |
dc.subject.MESH | Propionates/poisoning | - |
dc.subject.MESH | Quinoxalines/pharmacology | - |
dc.subject.MESH | Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors | - |
dc.subject.MESH | Superoxides/metabolism | - |
dc.title | Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Gyung W. Kim | - |
dc.contributor.googleauthor | Jean-Christophe copin | - |
dc.contributor.googleauthor | Makoto Kawase | - |
dc.contributor.googleauthor | Sylvia F. Chen | - |
dc.contributor.googleauthor | Shuzo Sato | - |
dc.contributor.googleauthor | Glenn T. Gobbel | - |
dc.contributor.googleauthor | Pak H. Chan | - |
dc.identifier.doi | 10.1097/00004647-200001000-00016 | - |
dc.contributor.localId | A00310 | - |
dc.relation.journalcode | J01306 | - |
dc.identifier.eissn | 1559-7016 | - |
dc.identifier.pmid | 10616800 | - |
dc.identifier.url | http://journals.sagepub.com/doi/abs/10.1097/00004647-200001000-00016 | - |
dc.subject.keyword | 3-Nitropropionic acid | - |
dc.subject.keyword | Striatum | - |
dc.subject.keyword | Mitochondria | - |
dc.subject.keyword | Excitotoxicity | - |
dc.subject.keyword | Superoxide | - |
dc.subject.keyword | Apoptosis | - |
dc.contributor.alternativeName | Kim, Gyung Whan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.citation.volume | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 119 | - |
dc.citation.endPage | 129 | - |
dc.identifier.bibliographicCitation | Journal of Cerebral Blood Flow and Metabolism, Vol.20(1) : 119-129, 2000 | - |
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