0 40

Cited 0 times in

Composite neuroendocrine and adenocarcinoma of the common bile duct associated with Clonorchis sinensis: a case report

Authors
 Se Hoon Kim  ;  Hoon Kim  ;  Young Nyun Park  ;  Nyun Park  ;  Dong Sup Yoon  ;  Sup Yoon  ;  Se Joon Lee  ;  Joon Lee  ;  Jeong Sik Yu  ;  Sik Yu  ;  Tae Woong Noh  ;  Woong Noh 
Citation
 Hepato-Gastroenterology, Vol.47(34) : 942-944, 2000 
Journal Title
 Hepato-Gastroenterology 
ISSN
 0172-6390 
Issue Date
2000
MeSH
Adenocarcinoma/pathology* ; Adenocarcinoma/surgery ; Carcinoma, Small Cell/pathology* ; Carcinoma, Small Cell/surgery ; Cholangiopancreatography, Endoscopic Retrograde ; Clonorchiasis/pathology* ; Common Bile Duct Neoplasms/pathology* ; Common Bile Duct Neoplasms/surgery ; Humans ; Male ; Middle Aged ; Tomography, X-Ray Computed
Abstract
The biliary tract has neuroendocrine cells of endoderm origin similar to the gastrointestinal tract, however neuroendocrine tumors of the biliary tract are rare. We report a composite glandular-endocrine cell carcinoma of the common bile duct in a 64-year-old Korean man which was associated with Clonorchis sinensis. The patient complained of right upper quadrant abdominal pain. Several parasites of Clonorchis sinensis were removed during the percutaneous transbiliary drainage. Endoscopic retrograde cholangiopancreatography revealed a polypoid mass (3 x 3 cm) with central ulceration in the common bile duct. Pancreaticoduodenectomy was performed. Microscopic examination of the tumor revealed a composite small cell neuroendocrine carcinoma and adenocarcinoma. The small cell carcinoma component showed positive reaction to chromogranin A and neuron-specific enolase and it was located mainly in the deeper portion of the mass. The well-differentiated adenocarcinoma component showed a positive reaction to carcinoembryonic antigen and it was situated in the superficial portion of the mass. Exclusively, the small cell component metastasized to the lymph node. It is suggested that this tumor could arise from a multipotential stem cell and showed neuroendocrine and glandular differentiation and that Clonorchis sinensis could be a predisposing factor, as in cholangiocarcinoma.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
Yoon, Dong Sup(윤동섭) ORCID logo https://orcid.org/0000-0001-6444-9606
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171645
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links