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Antisense of Human Peroxiredoxin II enhances Radiation-induced Cell Death

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dc.contributor.author김형중-
dc.date.accessioned2019-11-11T05:04:43Z-
dc.date.available2019-11-11T05:04:43Z-
dc.date.issued2000-
dc.identifier.issn1078-0432-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171595-
dc.description.abstractHuman peroxiredoxin II (Prx II) has been known to function as an antioxidant enzyme in cells. Using head-and-neck cancer cell lines, we investigated whether Prx II expression is related to the resistance of cells to radiation therapy in vivo and in vitro, and whether a Prx II antisense serves as a radiosensitizer. Increased expression of Prx II was observed in tissues isolated from the patients who did not respond to radiation therapy, whereas Prx II expression was weak in tissues from the patients with regressed tumors. Enhanced expression of Prx II in UMSCC-11A (11A) cells was also observed after treatment with gamma radiation. This increased expression conferred radiation resistance to cancer cells because overexpression of Prx II protected 11A cells from radiation-induced cell death, suggesting that blocking Prx II expression could enhance radiation sensitivity. Treatment of 11A cells with a Prx II antisense decreased induction of Prx II, enhancing the radiation sensitivity. From these results, we suggest that stress-induced overexpression of Prx II increases radiation resistance via protection of cancer cells from radiation-induced oxidative cytolysis and that a Prx II antisense can be used as a radiosensitizer.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Association for Cancer Research-
dc.relation.isPartOfClinical Cancer Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAntioxidants/metabolism-
dc.subject.MESHAntioxidants/therapeutic use*-
dc.subject.MESHApoptosis/drug effects-
dc.subject.MESHBlotting, Northern-
dc.subject.MESHCell Death/drug effects-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHDose-Response Relationship, Radiation-
dc.subject.MESHGamma Rays-
dc.subject.MESHHead and Neck Neoplasms/drug therapy-
dc.subject.MESHHead and Neck Neoplasms/pathology-
dc.subject.MESHHead and Neck Neoplasms/radiotherapy-
dc.subject.MESHHumans-
dc.subject.MESHImmunoblotting-
dc.subject.MESHOligonucleotides, Antisense/therapeutic use*-
dc.subject.MESHPeroxidases/metabolism-
dc.subject.MESHPeroxidases/therapeutic use*-
dc.subject.MESHPeroxiredoxins-
dc.subject.MESHRadiation Tolerance/drug effects*-
dc.subject.MESHRadiation-Sensitizing Agents/therapeutic use-
dc.subject.MESHTime Factors-
dc.subject.MESHTumor Cells, Cultured-
dc.titleAntisense of Human Peroxiredoxin II enhances Radiation-induced Cell Death-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSun-Hee Park-
dc.contributor.googleauthorYoung Min Chung-
dc.contributor.googleauthorYong-Sik Lee-
dc.contributor.googleauthorHyung Jung Kim-
dc.contributor.googleauthorJun Suk Kim-
dc.contributor.googleauthorHo Zoon Chae-
dc.contributor.googleauthorYoung Do Yoo-
dc.contributor.localIdA01158-
dc.relation.journalcodeJ00564-
dc.identifier.pmid11156252-
dc.contributor.alternativeNameKim, Hyung Jung-
dc.contributor.affiliatedAuthor김형중-
dc.citation.volume6-
dc.citation.number12-
dc.citation.startPage4915-
dc.citation.endPage4920-
dc.identifier.bibliographicCitationClinical Cancer Research, Vol.6(12) : 4915-4920, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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