Cited 24 times in
Mechanisms of ventricular fibrillation induction by 60-Hz alternating current in isolated swine right ventricle
DC Field | Value | Language |
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dc.contributor.author | 이문형 | - |
dc.date.accessioned | 2019-11-11T05:04:40Z | - |
dc.date.available | 2019-11-11T05:04:40Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0009-7322 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171594 | - |
dc.description.abstract | BACKGROUND: The mechanisms by which 60-Hz alternating current (AC) can induce ventricular fibrillation (VF) are unknown. METHODS AND RESULTS: We studied 7 isolated perfused swine right ventricles in vitro. The action potential duration restitution curve was determined. Optical mapping techniques were used to determine the patterns of activation on the epicardium during 5-second 60-Hz AC stimulation (10 to 999 microA). AC captured the right ventricles at 100+/-65 microA, which is significantly lower than the direct current pacing threshold (0.77+/-0.45 mA, P:<0.05). AC induced ventricular tachycardia or VF at 477+/-266 microA, when the stimulated responses to AC had (1) short activation CLs (128+/-14 ms), (2) short diastolic intervals (16+/-9 ms), and (3) short diastolic intervals associated with a steep action potential duration restitution curve. Optical mapping studies showed that during rapid ventricular stimulation by AC, a wave front might encounter the refractory tail of an earlier wave front, resulting in the formation of a wave break and VF. Computer simulations reproduced these results. CONCLUSIONS: AC at strengths less than the regular pacing threshold can capture the ventricle at fast rates. Accidental AC leak to the ventricles could precipitate VF and sudden death if AC results in a fast ventricular rate coupled with a steep restitution curve and a nonuniform recovery of excitability of the myocardium. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | Circulation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Electricity/adverse effects* | - |
dc.subject.MESH | Heart Ventricles/physiopathology | - |
dc.subject.MESH | Swine | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Ventricular Fibrillation/etiology* | - |
dc.subject.MESH | Ventricular Fibrillation/physiopathology | - |
dc.title | Mechanisms of ventricular fibrillation induction by 60-Hz alternating current in isolated swine right ventricle | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Voroshilovsky, Olga | - |
dc.contributor.googleauthor | Qu, Zhilin | - |
dc.contributor.googleauthor | Lee, Moon-Hyoung | - |
dc.contributor.googleauthor | Ohara, Toshihiko | - |
dc.contributor.googleauthor | Fishbein, Gregory A. | - |
dc.contributor.googleauthor | Huang, Hsun-Lun A. | - |
dc.contributor.googleauthor | Swerdlow, Charles D. | - |
dc.contributor.googleauthor | Lin, Shien-Fong | - |
dc.contributor.googleauthor | Garfinkel, Alan | - |
dc.contributor.googleauthor | Weiss, James N. | - |
dc.contributor.googleauthor | Karagueuzian, Hrayr S. | - |
dc.contributor.googleauthor | Chen, Peng-Sheng | - |
dc.identifier.doi | 10.1161/01.cir.102.13.1569 | - |
dc.contributor.localId | A02766 | - |
dc.relation.journalcode | J00533 | - |
dc.identifier.eissn | 1524-4539 | - |
dc.identifier.pmid | 11004149 | - |
dc.identifier.url | https://www.ahajournals.org/doi/full/10.1161/01.cir.102.13.1569 | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | 이문형 | - |
dc.citation.volume | 102 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 1569 | - |
dc.citation.endPage | 1574 | - |
dc.identifier.bibliographicCitation | Circulation, Vol.102(13) : 1569-1574, 2000 | - |
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