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Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng.

Authors
 Young-Sam Keum  ;  Kwang-Kyun Park  ;  Jong-Min Lee  ;  Kyung-Soo Chun  ;  Jeong Hill Park  ;  Seung Ki Lee  ;  Hoonjeong Kwon  ;  Young-Joon Surh 
Citation
 Cancer Letters, Vol.150(1) : 41-48, 2000 
Journal Title
CANCER LETTERS
ISSN
 0304-3835 
Issue Date
2000
MeSH
9,10-Dimethyl-1,2-benzanthracene/adverse effects ; Animals ; Anticarcinogenic Agents/pharmacology* ; Antioxidants/pharmacology* ; Bacteriophage phi X 174/genetics ; Brain/drug effects ; Brain/metabolism ; Carcinogens/adverse effects ; DNA, Viral/drug effects ; DNA, Viral/genetics ; DNA, Viral/radiation effects ; Enzyme Activation/drug effects ; Female ; Gene Expression Regulation, Enzymologic/drug effects ; HL-60 Cells ; Hot Temperature ; Humans ; Hydrogen Peroxide/adverse effects ; Lipid Peroxidation/drug effects ; Male ; Methanol ; Mice ; Mice, Inbred ICR ; Ornithine Decarboxylase/drug effects ; Ornithine Decarboxylase/genetics ; Ornithine Decarboxylase/metabolism ; Panax/chemistry* ; Papilloma/chemically induced ; Papilloma/prevention & control ; Plant Extracts/chemistry ; Plant Extracts/pharmacology* ; Plants, Medicinal* ; RNA, Messenger/drug effects ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Skin/drug effects ; Skin/metabolism ; Skin/pathology ; Skin Neoplasms/chemically induced ; Skin Neoplasms/prevention & control ; Superoxides/metabolism ; Tetradecanoylphorbol Acetate/adverse effects ; Tumor Necrosis Factor-alpha/drug effects ; Tumor Necrosis Factor-alpha/metabolism ; Ultraviolet Rays/adverse effects
Keywords
Ginseng ; Antioxidant ; Anti-tumor promotion ; Mouse skin carcinogenesis ; Ornithine decarboxylase
Abstract
Heat treatment of Panax ginseng C.A. Meyer at a temperature higher than that applied to the conventional preparation of red ginseng yielded a mixture of saponins with potent antioxidative properties. Thus, the methanol extract of heat-processed neoginseng (designated as 'NGMe') attenuated lipid peroxidation in rat brain homogenates induced by ferric ion or ferric ion plus ascorbic acid. Furthermore, the extract protected against strand scission in phiX174 supercoiled DNA induced by UV photolysis of H2O2, and was also capable of scavenging superoxide generated by xanthine-xanthine oxidase or by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocytic leukemia (HL-60) cells. Topical application of NGMe onto shaven backs of female ICR mice 10 min prior to TPA, significantly ameliorated skin papillomagenesis initiated by 7,12-dimethylbenz[a]anthracene. Moreover, TPA-induced enhancement of epidermal ornithine decarboxylase (ODC) activity and ODC mRNA expression was abolished by a topical dose (0.68 mg) of NGMe. Likewise, TPA-induced production of tumor necrosis factor- in mouse skin was inhibited by NGMe pretreatment.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304383599003699
DOI
10.1016/S0304-3835(99)00369-9
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171586
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