Cited 38 times in
The Methylentetrahydrofolate reductase gene is associated with increased cardiovascular risk in Japan, but not in other population.
DC Field | Value | Language |
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dc.contributor.author | 서일 | - |
dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2019-11-11T05:02:33Z | - |
dc.date.available | 2019-11-11T05:02:33Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171563 | - |
dc.description.abstract | The methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased risk for cardiovascular disease in some, but not all studies. Our data sources included a MEDLINE search of the literature published before December 1998, a bibliography review, and expert consultation. Of 23 studies initially identified, 18 (9855 persons) met the inclusion criteria. Information on sample size, study design, Hardy-Weinberg equilibrium, method of genotype determination, plasma folate and homocysteine were abstracted by two reviewers using a standardized protocol. The overall odds ratio of the MTHFR gene on cardiovascular disease was estimated using the Mantel-Haenzel method. From 12 studies with angiographically-confirmed coronary artery disease (CAD), the overall odds ratio (OR) for CAD among those with heterozygous (V/A) was 1.3 (95% CI, 1.1-1.5), while it was 1.4 (1.2-1.6) for the homozygous mutant (V/V) compared to those with homozygous normal (A/A). However, the overall odds ratio for CAD among those with the V/V genotype versus A/A genotype was not statistically significant (OR: 1.1; 95% CI: 0.9-1.3) after excluding three Japanese studies. The corresponding OR for the three Japanese studies was 2.0 (1.6-2.7). For six studies with myocardial infarction (MI), the overall OR of MI was 1.0 (0.8-1.1) for those with the V/A genotype and 0.9 (0.7-1.1) for those with the V/V genotype, respectively; none of these ORs for MI was statistically significant. The MTHFR gene is associated with increased risk for CAD in Japan, but not in other populations. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | Atherosclerosis | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics* | - |
dc.subject.MESH | Cardiovascular Diseases/genetics* | - |
dc.subject.MESH | Coronary Disease/genetics | - |
dc.subject.MESH | Genetic Predisposition to Disease* | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Japan | - |
dc.subject.MESH | Methylenetetrahydrofolate Reductase (NADPH2) | - |
dc.subject.MESH | Myocardial Infarction/genetics | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Oxidoreductases Acting on CH-NH Group Donors/genetics* | - |
dc.title | The Methylentetrahydrofolate reductase gene is associated with increased cardiovascular risk in Japan, but not in other population. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.contributor.googleauthor | Terri H. Beaty | - |
dc.contributor.googleauthor | Il Suh | - |
dc.contributor.googleauthor | Young-sup Yoon | - |
dc.contributor.googleauthor | Lawrence J. Appel | - |
dc.identifier.doi | 10.1016/S0021-9150(00)00389-0 | - |
dc.contributor.localId | A01899 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J00260 | - |
dc.identifier.eissn | 1879-1484 | - |
dc.identifier.pmid | 11058711 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0021915000003890 | - |
dc.subject.keyword | Genotype | - |
dc.subject.keyword | MTHFR | - |
dc.subject.keyword | Coronary artery disease | - |
dc.subject.keyword | Myocardial infarction | - |
dc.subject.keyword | Racial difference | - |
dc.contributor.alternativeName | Suh, Il | - |
dc.contributor.affiliatedAuthor | 서일 | - |
dc.contributor.affiliatedAuthor | 지선하 | - |
dc.citation.volume | 153 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 161 | - |
dc.citation.endPage | 168 | - |
dc.identifier.bibliographicCitation | Atherosclerosis, Vol.153(1) : 161-168, 2000 | - |
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