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Skin Flap Prefabrication using Acellular Dermal Matrix and Cultured Keratinocytes in the Porcine Model

Authors
 Tark Kwan-Chul  ;  Chung, Seum  ;  Shin, Keuk-Shun  ;  Park, Beyoung-Yun 
Citation
 Annals of Plastic Surgery, Vol.44(4) : 392-397, 2000 
Journal Title
 Annals of Plastic Surgery 
ISSN
 0148-7043 
Issue Date
2000
MeSH
Animals ; Cells, Cultured ; Disease Models, Animal ; Keratinocytes* ; Skin, Artificial* ; Surgical Flaps* ; Swine ; Wound Healing
Abstract
In an effort to minimize the amount of autogenous tissue that is sacrificed in using a random skin flap, the authors, in a porcine model, implanted 3.0 x 7.0-cm (median thickness, 1 mm) sheets of commercially available nonmeshed acellular dermal matrix (AlloDerm) subcutaneously. After a vascularization period of 2 weeks, the implants were elevated and used as turnover dermal flaps to cover adjacent 3.0 x 3.0-cm full-thickness skin defects. Sheets of autogenous cultured keratinocytes were used for epithelium. The AlloDerm-cultured keratinocyte complex flaps healed without any complications. Measurements for percent contraction of the wound to determine the suitability of AlloDerm as a dermal flap showed that the wounds had contracted an average of 18 +/- 3.6% at 24 weeks. Histological evaluation revealed multilayered keratinocytes and indurations between the cultured keratinocytes and AlloDerm. Fibroblast infiltration and the presence of luminal spaces surrounded by capillary endothelium characteristic of neovascularization of the matrix were also noted. This preliminary study may form the basis for developing other types of prefabricated flaps using AlloDerm and cultured keratinocytes
Full Text
https://journals.lww.com/annalsplasticsurgery/Citation/2000/44040/Skin_Flap_Prefabrication_Using_Acellular_Dermal.7.aspx
DOI
10.1097/00000637-200044040-00007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Tark, Kwan Chul(탁관철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171549
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