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Utilization of HbA1c in Screening Living Kidney Donors With Prediabetes

 Joon Chae Na  ;  Min-Gee Yoon  ;  Hyung Ho Lee  ;  Young Eun Yoon  ;  Deok Gie Kim  ;  Kyu Ha Huh  ;  Yu Seun Kim  ;  Woong Kyu Han 
 Transplantation Proceedings, Vol.51(8) : 2527-2532, 2019 
Journal Title
 Transplantation Proceedings 
Issue Date
OBJECTIVES: To study the outcome of living kidney donors with prediabetes and to evaluate the utilization of baseline HbA1c to identify donors at high risk for developing diabetes during the postdonation follow-up period. PATIENTS AND METHODS: Living kidney donors with prospectively collected preoperative fasting glucose and HbA1c results were included in the study. Donors were categorized to the high-risk group when both results were in the prediabetic range, the low-risk group when only 1 result was in the prediabetic range, and the control group when both results were normal. RESULTS: Ninety-three donors were followed for 75.9 ± 23.3 months. A higher proportion of donors in the high-risk group progressed to diabetes compared with donors in the low-risk and control groups (31.3% vs 6.5% vs 0.0%, respectively; P < .001). Donors with prediabetes were not at a higher risk for new-onset hypertension (4.4% vs 10.0% vs 7.7%, in control, low-risk, and high-risk groups, respectively; P = .519) or microproteinuria (7.3% vs 10.3% vs 0.0%, in control, low-risk, and high-risk groups, respectively; P = .478) and exhibited equivalent postdonation renal function compared with donors with normal glucose metabolism. CONCLUSIONS: HbA1c can identify donors with prediabetes who are at risk for progression to diabetes. Our results indicate that carefully accepted donors with prediabetes are not at increased risk of renal function deterioration in the immediate postdonation period.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Deok Gie(김덕기)
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Na, Joon Chae(나준채) ORCID logo https://orcid.org/0000-0003-4449-8472
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
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