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Optimized Treatment for Infantile Spasms: Vigabatrin versus Prednisolone versus Combination Therapy

DC FieldValueLanguage
dc.contributor.author강훈철-
dc.contributor.author김세희-
dc.contributor.author김흥동-
dc.contributor.author이준수-
dc.date.accessioned2019-10-28T02:06:52Z-
dc.date.available2019-10-28T02:06:52Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171492-
dc.description.abstractHormone therapies and vigabatrin are first-line agents in infantile spasms, but more than one-third of patients fail to respond to these treatments. This was a retrospective study of patients with infantile spasms who were treated between January 2005 and December 2017. We analyzed the response rates of initial treatment and second-line treatment. Responders were defined as those in whom cessation of spasms was observed for a period of at least one month, within 2 weeks of treatment initiation. Regarding the response rate to initial treatment, combination therapy of vigabatrin with prednisolone showed a significantly better response than that of vigabatrin monotherapy (55.3% vs. 39.1%, p = 0.037). Many drugs, such as clobazam, topiramate, and levetiracetam, were used as second-line agents after the failure of vigabatrin. Among these, no antiepileptic drug showed as good a response as prednisolone. For patients who used prednisolone, the proportion of responders was significantly higher in the higher-dose group (≥40 mg/day) than in the lower-dose group (66.7% vs. 12.5%, p = 0.028). Further studies of combination therapy to assess dosage protocols and long-term outcomes are needed.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJournal of Clinical Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleOptimized Treatment for Infantile Spasms: Vigabatrin versus Prednisolone versus Combination Therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorJongsung Hahn-
dc.contributor.googleauthorGyunam Park-
dc.contributor.googleauthorHoon-Chul Kang-
dc.contributor.googleauthorJoon Soo Lee-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorSe Hee Kim-
dc.contributor.googleauthorMin Jung Chang-
dc.identifier.doi10.3390/jcm8101591-
dc.contributor.localIdA00102-
dc.contributor.localIdA00611-
dc.contributor.localIdA00611-
dc.contributor.localIdA01208-
dc.contributor.localIdA01208-
dc.contributor.localIdA03177-
dc.contributor.localIdA03177-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid31581698-
dc.subject.keywordCombination of vigabatrin with prednisolone-
dc.subject.keywordFirst-line treatment-
dc.subject.keywordHigher dose of prednisolone-
dc.subject.keywordInfantile spasms-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.contributor.affiliatedAuthor강훈철-
dc.contributor.affiliatedAuthor김세희-
dc.contributor.affiliatedAuthor김세희-
dc.contributor.affiliatedAuthor김흥동-
dc.contributor.affiliatedAuthor김흥동-
dc.contributor.affiliatedAuthor이준수-
dc.contributor.affiliatedAuthor이준수-
dc.citation.volume8-
dc.citation.number10-
dc.citation.startPageE1591-
dc.identifier.bibliographicCitationJournal of Clinical Medicine, Vol.8(10) : E1591, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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