Cited 11 times in
Optimized Treatment for Infantile Spasms: Vigabatrin versus Prednisolone versus Combination Therapy
DC Field | Value | Language |
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dc.contributor.author | 강훈철 | - |
dc.contributor.author | 김세희 | - |
dc.contributor.author | 김흥동 | - |
dc.contributor.author | 이준수 | - |
dc.date.accessioned | 2019-10-28T02:06:52Z | - |
dc.date.available | 2019-10-28T02:06:52Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171492 | - |
dc.description.abstract | Hormone therapies and vigabatrin are first-line agents in infantile spasms, but more than one-third of patients fail to respond to these treatments. This was a retrospective study of patients with infantile spasms who were treated between January 2005 and December 2017. We analyzed the response rates of initial treatment and second-line treatment. Responders were defined as those in whom cessation of spasms was observed for a period of at least one month, within 2 weeks of treatment initiation. Regarding the response rate to initial treatment, combination therapy of vigabatrin with prednisolone showed a significantly better response than that of vigabatrin monotherapy (55.3% vs. 39.1%, p = 0.037). Many drugs, such as clobazam, topiramate, and levetiracetam, were used as second-line agents after the failure of vigabatrin. Among these, no antiepileptic drug showed as good a response as prednisolone. For patients who used prednisolone, the proportion of responders was significantly higher in the higher-dose group (≥40 mg/day) than in the lower-dose group (66.7% vs. 12.5%, p = 0.028). Further studies of combination therapy to assess dosage protocols and long-term outcomes are needed. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Journal of Clinical Medicine | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Optimized Treatment for Infantile Spasms: Vigabatrin versus Prednisolone versus Combination Therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Jongsung Hahn | - |
dc.contributor.googleauthor | Gyunam Park | - |
dc.contributor.googleauthor | Hoon-Chul Kang | - |
dc.contributor.googleauthor | Joon Soo Lee | - |
dc.contributor.googleauthor | Heung Dong Kim | - |
dc.contributor.googleauthor | Se Hee Kim | - |
dc.contributor.googleauthor | Min Jung Chang | - |
dc.identifier.doi | 10.3390/jcm8101591 | - |
dc.contributor.localId | A00102 | - |
dc.contributor.localId | A00611 | - |
dc.contributor.localId | A01208 | - |
dc.contributor.localId | A03177 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 31581698 | - |
dc.subject.keyword | Combination of vigabatrin with prednisolone | - |
dc.subject.keyword | First-line treatment | - |
dc.subject.keyword | Higher dose of prednisolone | - |
dc.subject.keyword | Infantile spasms | - |
dc.contributor.alternativeName | Kang, Hoon Chul | - |
dc.contributor.affiliatedAuthor | 강훈철 | - |
dc.contributor.affiliatedAuthor | 김세희 | - |
dc.contributor.affiliatedAuthor | 김흥동 | - |
dc.contributor.affiliatedAuthor | 이준수 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | E1591 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Medicine, Vol.8(10) : E1591, 2019 | - |
dc.identifier.rimsid | 63722 | - |
dc.type.rims | ART | - |
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