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The prognostic significance of preoperative tumor marker (CEA, CA15-3) elevation in breast cancer patients: data from the Korean Breast Cancer Society Registry

DC FieldValueLanguage
dc.contributor.author정준-
dc.date.accessioned2019-10-28T02:04:09Z-
dc.date.available2019-10-28T02:04:09Z-
dc.date.issued2019-
dc.identifier.issn0167-6806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171468-
dc.description.abstractPURPOSE: Tumor markers such as carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) are widely used for monitoring breast cancer. However, the prognostic efficacy of preoperative elevations of CEA and CA15-3 levels in breast cancer patients remains controversial. METHODS: We retrospectively analyzed the clinicopathological parameters of 149,238 patients in the Korean Breast Cancer Society Registry Database who underwent surgery between January 2000 and December 2015. RESULTS: The patients with elevated CA15-3/CEA levels had worse overall survival (OS) than the patients with normal CA15-3/CEA levels. For the luminal A subtype, the CA15-3- and CEA-elevated group had a hazard ratio (HR) of 2.14 (95% CI 1.01-4.55). The CA15-3-elevated group had an HR of 2.38 (95% CI 1.58-3.58) and the CEA-elevated group had an HR of 1.79 (95% CI 1.20-2.68) compared to the normal group. For the luminal B subtype, the CA15-3- and CEA-elevated group had an HR of 3.99 (95% CI 2.23-7.16), whereas the CA15-3-elevated group had an HR of 2.38 (95% CI 1.58-3.58) and the CEA-elevated group had an HR of 1.79 (95% CI 1.20-2.68). For the HER2 subtype, elevated CEA level was the only independent prognostic factor. However, for the triple-negative breast cancer (TNBC) subtype, elevated preoperative CEA and CA15-3 levels were not significant prognostic factors for OS. CONCLUSION: Preoperative CEA and CA15-3 levels showed varying prognostic ability according to breast cancer subtype. Preoperative CA15-3 and CEA elevation are significant prognostic factors for luminal breast cancer, but they were not significant factors for TNBC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherKluwer Academic-
dc.relation.isPartOfBreast Cancer Research and Treatment-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleThe prognostic significance of preoperative tumor marker (CEA, CA15-3) elevation in breast cancer patients: data from the Korean Breast Cancer Society Registry-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSang eun Nam-
dc.contributor.googleauthorWoosung Lim-
dc.contributor.googleauthorJoon Jeong-
dc.contributor.googleauthorSeeyoun Lee-
dc.contributor.googleauthorJungeun Choi-
dc.contributor.googleauthorHeungKyu Park-
dc.contributor.googleauthorYong Sik Jung-
dc.contributor.googleauthorSeung Pil Jung-
dc.contributor.googleauthorSoo Youn Bae-
dc.identifier.doi10.1007/s10549-019-05357-y-
dc.contributor.localIdA03727-
dc.relation.journalcodeJ00403-
dc.identifier.eissn1573-7217-
dc.identifier.pmid31312932-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs10549-019-05357-y-
dc.subject.keywordBreast cancer-
dc.subject.keywordCA15-3-
dc.subject.keywordCEA-
dc.subject.keywordOverall survival-
dc.subject.keywordPrognosis-
dc.subject.keywordSubtypes-
dc.subject.keywordTumor marker-
dc.contributor.alternativeNameJeong, Joon-
dc.contributor.affiliatedAuthor정준-
dc.citation.volume177-
dc.citation.number3-
dc.citation.startPage669-
dc.citation.endPage678-
dc.identifier.bibliographicCitationBreast Cancer Research and Treatment, Vol.177(3) : 669-678, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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