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The prognostic significance of preoperative tumor marker (CEA, CA15-3) elevation in breast cancer patients: data from the Korean Breast Cancer Society Registry
DC Field | Value | Language |
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dc.contributor.author | 정준 | - |
dc.date.accessioned | 2019-10-28T02:04:09Z | - |
dc.date.available | 2019-10-28T02:04:09Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171468 | - |
dc.description.abstract | PURPOSE: Tumor markers such as carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) are widely used for monitoring breast cancer. However, the prognostic efficacy of preoperative elevations of CEA and CA15-3 levels in breast cancer patients remains controversial. METHODS: We retrospectively analyzed the clinicopathological parameters of 149,238 patients in the Korean Breast Cancer Society Registry Database who underwent surgery between January 2000 and December 2015. RESULTS: The patients with elevated CA15-3/CEA levels had worse overall survival (OS) than the patients with normal CA15-3/CEA levels. For the luminal A subtype, the CA15-3- and CEA-elevated group had a hazard ratio (HR) of 2.14 (95% CI 1.01-4.55). The CA15-3-elevated group had an HR of 2.38 (95% CI 1.58-3.58) and the CEA-elevated group had an HR of 1.79 (95% CI 1.20-2.68) compared to the normal group. For the luminal B subtype, the CA15-3- and CEA-elevated group had an HR of 3.99 (95% CI 2.23-7.16), whereas the CA15-3-elevated group had an HR of 2.38 (95% CI 1.58-3.58) and the CEA-elevated group had an HR of 1.79 (95% CI 1.20-2.68). For the HER2 subtype, elevated CEA level was the only independent prognostic factor. However, for the triple-negative breast cancer (TNBC) subtype, elevated preoperative CEA and CA15-3 levels were not significant prognostic factors for OS. CONCLUSION: Preoperative CEA and CA15-3 levels showed varying prognostic ability according to breast cancer subtype. Preoperative CA15-3 and CEA elevation are significant prognostic factors for luminal breast cancer, but they were not significant factors for TNBC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Kluwer Academic | - |
dc.relation.isPartOf | Breast Cancer Research and Treatment | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The prognostic significance of preoperative tumor marker (CEA, CA15-3) elevation in breast cancer patients: data from the Korean Breast Cancer Society Registry | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Sang eun Nam | - |
dc.contributor.googleauthor | Woosung Lim | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.contributor.googleauthor | Seeyoun Lee | - |
dc.contributor.googleauthor | Jungeun Choi | - |
dc.contributor.googleauthor | HeungKyu Park | - |
dc.contributor.googleauthor | Yong Sik Jung | - |
dc.contributor.googleauthor | Seung Pil Jung | - |
dc.contributor.googleauthor | Soo Youn Bae | - |
dc.identifier.doi | 10.1007/s10549-019-05357-y | - |
dc.contributor.localId | A03727 | - |
dc.relation.journalcode | J00403 | - |
dc.identifier.eissn | 1573-7217 | - |
dc.identifier.pmid | 31312932 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10549-019-05357-y | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | CA15-3 | - |
dc.subject.keyword | CEA | - |
dc.subject.keyword | Overall survival | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Subtypes | - |
dc.subject.keyword | Tumor marker | - |
dc.contributor.alternativeName | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | 정준 | - |
dc.citation.volume | 177 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 669 | - |
dc.citation.endPage | 678 | - |
dc.identifier.bibliographicCitation | Breast Cancer Research and Treatment, Vol.177(3) : 669-678, 2019 | - |
dc.identifier.rimsid | 63218 | - |
dc.type.rims | ART | - |
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