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Modified Colon Leakage Score to Predict Anastomotic Leakage in Patients Who Underwent Left-Sided Colorectal Surgery

DC FieldValueLanguage
dc.contributor.author강정현-
dc.contributor.author백승혁-
dc.contributor.author이강영-
dc.contributor.author박은정-
dc.date.accessioned2019-10-28T02:03:32Z-
dc.date.available2019-10-28T02:03:32Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171462-
dc.description.abstractColon leakage score (CLS) was introduced as a clinical tool to predict anastomotic leakage (AL) in patients who underwent left-sided colorectal surgery, but its clinical validity has not been widely studied. We evaluated the clinical utility of CLS and developed a modified CLS (m-CLS). In total, 566 patients who underwent left-sided colorectal surgery were enrolled and categorized into training (n = 396) and validation (n = 170) sets via random sampling. Using CLS variables, the least absolute shrinkage and selection operator (LASSO) regression model was applied for variable selection and predictive signature building in the training set. The model's performance was validated in the validation set. The predictive powers of m-CLS and CLS were compared by the area under the receiver operating characteristic (AUROC) curve in the overall group. Twenty-three AL events (4.1%) were noted. The AL group had a significantly higher mean CLS than the No Leakage group (12.5 vs. 9.6, p = 0.001). Five clinical variables were selected and used to generate m-CLS. The predictive performance of m-CLS was similar in training and validation sets (AUROC 0.838 vs. 0.803, p = 0.724). In the overall set, m-CLS was significantly predictive of AL and performed better than CLS (AUROC 0.831 vs. 0.701, p = 0.008). In conclusion, LASSO-model-generated m-CLS could predict AL more accurately than CLS.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJournal of Clinical Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleModified Colon Leakage Score to Predict Anastomotic Leakage in Patients Who Underwent Left-Sided Colorectal Surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSeung Up Yang-
dc.contributor.googleauthorEun Jung Park-
dc.contributor.googleauthorSeung Hyuk Baik-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorJeonghyun Kang-
dc.identifier.doi10.3390/jcm8091450-
dc.contributor.localIdA00080-
dc.contributor.localIdA01827-
dc.contributor.localIdA01827-
dc.contributor.localIdA02640-
dc.contributor.localIdA02640-
dc.contributor.localIdA04572-
dc.contributor.localIdA04572-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid31547283-
dc.subject.keywordLASSO-
dc.subject.keywordanastomotic leakage-
dc.subject.keywordarea under the curve-
dc.subject.keywordcolorectal cancer-
dc.subject.keywordrectal neoplasms-
dc.contributor.alternativeNameKang, Jeonghyun-
dc.contributor.affiliatedAuthor강정현-
dc.contributor.affiliatedAuthor백승혁-
dc.contributor.affiliatedAuthor백승혁-
dc.contributor.affiliatedAuthor이강영-
dc.contributor.affiliatedAuthor이강영-
dc.contributor.affiliatedAuthor박은정-
dc.contributor.affiliatedAuthor박은정-
dc.citation.volume8-
dc.citation.number9-
dc.citation.startPageE1450-
dc.identifier.bibliographicCitationJournal of Clinical Medicine, Vol.8(9) : E1450, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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