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Chemoselective Radiosyntheses of Electron-Rich [18F]Fluoroarenes from Aryl(2,4,6-trimethoxyphenyl)iodonium Tosylates

Authors
 Young-Do Kwon  ;  Jeongmin Son  ;  Joong-Hyun Chun 
Citation
 Journal of Organic Chemistry, Vol.84(6) : 3678-3686, 2019 
Journal Title
 Journal of Organic Chemistry 
ISSN
 0022-3263 
Issue Date
2019
Abstract
Hypervalent diaryliodonium salts have been used to produce various [18F]fluoroarenes. The iodonium salt approach as a labeling precursor has been established to equally afford complex 18F-fluorinated molecules. Because of the inherent two aryl ring system connected to a central iodine atom, safeguarding the chemoselectivity during radiofluorination using diaryliodonium salts is important. Herein, we introduce a superior chemoselective radiosynthesis of [18F]fluoroarenes using an aryl(2,4,6-trimethoxyphenyl)iodonium tosylate as a precursor for 18F-incorporation, even on electron-rich aryl rings.
Full Text
https://pubs.acs.org/doi/10.1021/acs.joc.9b00019
DOI
10.1021/acs.joc.9b00019
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Chun, Joong-Hyun(전중현) ORCID logo https://orcid.org/0000-0002-9665-7829
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171432
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