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Cited 4 times in

Effect of Radiotherapy Combined With Pembrolizumab on Local Tumor Control in Mucosal Melanoma Patients

DC FieldValueLanguage
dc.contributor.author금웅섭-
dc.contributor.author노미령-
dc.contributor.author신상준-
dc.contributor.author오병호-
dc.contributor.author정기양-
dc.contributor.author장지석-
dc.date.accessioned2019-10-28T01:54:31Z-
dc.date.available2019-10-28T01:54:31Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171397-
dc.description.abstractObjective: Mucosal melanoma is an aggressive malignancy with a poor response to conventional therapies. The efficacy of radiotherapy (RT), especially combined with immune checkpoint inhibitors (ICIs), for this rare melanoma subtype remains unknown. We investigated the reciprocal effect of RT and ICI on mucosal melanoma patients. Materials and Methods: We identified 23 patients with 31 tumors who were treated with RT between July 2008 and February 2017. All patients received RT for primary or metastatic gross tumor mass with a median dose of 4 Gy per fraction (range 1.8-12 Gy). Eleven patients (14 lesions) were treated with RT alone, whereas 12 (17 lesions) were administered pembrolizumab combined with RT (ICI+RT group). The local control (LC) and adverse event (AE) rates were compared between the groups. Eight patients with metastatic mucosal melanoma treated with ICI alone during the same study period were included as a comparison group. Results: The median follow-up period was 17.4 (range 3.7-95.2) months. The target lesion control rate at 1-year was significantly higher in the ICI+RT group than in the RT-alone group or ICI-alone group (94.1% vs. 57.1% vs. 25%; P < 0.05). No abscopal effect was observed in our cohort. Treatment-related AEs were not significantly increased in the combined treatment group compared with the RT-alone group (P > 0.05). No grade ≥3 AEs occurred in the ICI+RT group. Conclusions: Besides RT acting as an immune adjuvant, ICI might have a radiosensitizing effect and may increase LC without severe toxicity. We have initiated a phase II study to determine the effects of RT in patients with melanoma undergoing anti-PD1 (NCT04017897).-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFrontiers in Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffect of Radiotherapy Combined With Pembrolizumab on Local Tumor Control in Mucosal Melanoma Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorHyun Ju Kim-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorMi Ryung Roh-
dc.contributor.googleauthorByung Ho Oh-
dc.contributor.googleauthorKee-Yang Chung-
dc.contributor.googleauthorSang Joon Shin-
dc.contributor.googleauthorWoong Sub Koom-
dc.identifier.doi10.3389/fonc.2019.00835-
dc.contributor.localIdA00273-
dc.contributor.localIdA01278-
dc.contributor.localIdA01278-
dc.contributor.localIdA02105-
dc.contributor.localIdA02105-
dc.contributor.localIdA02367-
dc.contributor.localIdA02367-
dc.contributor.localIdA03582-
dc.contributor.localIdA03582-
dc.contributor.localIdA04658-
dc.contributor.localIdA04658-
dc.relation.journalcodeJ03512-
dc.identifier.eissn2234-943X-
dc.identifier.pmid31552171-
dc.subject.keywordadverse events-
dc.subject.keywordimmunotherapy-
dc.subject.keywordlocal control-
dc.subject.keywordmelanoma-
dc.subject.keywordradiotherapy-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.affiliatedAuthor금웅섭-
dc.contributor.affiliatedAuthor노미령-
dc.contributor.affiliatedAuthor노미령-
dc.contributor.affiliatedAuthor신상준-
dc.contributor.affiliatedAuthor신상준-
dc.contributor.affiliatedAuthor오병호-
dc.contributor.affiliatedAuthor오병호-
dc.contributor.affiliatedAuthor정기양-
dc.contributor.affiliatedAuthor정기양-
dc.contributor.affiliatedAuthor장지석-
dc.contributor.affiliatedAuthor장지석-
dc.citation.volume9-
dc.citation.startPage835-
dc.identifier.bibliographicCitationFrontiers in Oncology, Vol.9 : 835, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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