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Higher glucagon-to-insulin ratio is associated with elevated glycated hemoglobin levels in type 2 diabetes patients

DC FieldValueLanguage
dc.contributor.author강신애-
dc.contributor.author김경래-
dc.contributor.author김민경-
dc.contributor.author박종숙-
dc.contributor.author안철우-
dc.contributor.author유지홍-
dc.contributor.author이민영-
dc.date.accessioned2019-10-28T01:53:04Z-
dc.date.available2019-10-28T01:53:04Z-
dc.date.issued2019-
dc.identifier.issn1226-3303-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171385-
dc.description.abstractBACKGROUND/AIMS: The importance of α-cell dysfunction in the pathogenesis of type 2 diabetes has re-emerged recently. However, data on whether relative glucagon excess is present in clinical settings are scarce. We aimed to investigate associations between glucagon-to-insulin ratio and various metabolic parameters. METHODS: A total of 451 patients with type 2 diabetes naïve to insulin treatment were recruited. Using glucagon-to-insulin ratio, we divided subjects into quartiles according to both fasting and postprandial glucagon-to-insulin ratios. RESULTS: The mean age of the subjects was 58 years, with a mean body mass index of 25 kg/m2 . The patients in the highest quartile of glucagon-to-insulin ratio had higher glycated hemoglobin (HbA1c) levels. HbA1c levels were positively correlated with both fasting and postprandial glucagon-to-insulin ratios. Subjects in the highest quartile of postprandial glucagon-to-insulin ratio were more likely to exhibit uncontrolled hyperglycemia, even after adjusting for confounding factors (odds ratio, 2.730; 95% confidence interval, 1.236 to 6.028; p for trend < 0.01). CONCLUSION: Hyperglucagonemia relative to insulin could contribute to uncontrolled hyperglycemia in type 2 diabetes patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Association of Internal Medicine-
dc.relation.isPartOfKorean Journal of Internal Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHigher glucagon-to-insulin ratio is associated with elevated glycated hemoglobin levels in type 2 diabetes patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorMinyoung Lee-
dc.contributor.googleauthorMinkyung Kim-
dc.contributor.googleauthorJong Suk Park-
dc.contributor.googleauthorSangbae Lee-
dc.contributor.googleauthorJihong You-
dc.contributor.googleauthorChul Woo Ahn-
dc.contributor.googleauthorKyung Rae Kim-
dc.contributor.googleauthorShinae Kang-
dc.identifier.doi10.3904/kjim.2016.233-
dc.contributor.localIdA00052-
dc.contributor.localIdA00294-
dc.contributor.localIdA00294-
dc.contributor.localIdA00457-
dc.contributor.localIdA00457-
dc.contributor.localIdA01660-
dc.contributor.localIdA01660-
dc.contributor.localIdA02270-
dc.contributor.localIdA02270-
dc.contributor.localIdA04984-
dc.contributor.localIdA04984-
dc.contributor.localIdA05491-
dc.contributor.localIdA05491-
dc.relation.journalcodeJ02883-
dc.identifier.eissn2005-6648-
dc.identifier.pmid28882024-
dc.subject.keywordDiabetes mellitus, type 2-
dc.subject.keywordGlucagon-
dc.subject.keywordHemoglobin A, glycosylated-
dc.subject.keywordHyperglycemia-
dc.subject.keywordInsulin-
dc.contributor.alternativeNameKang, Shin Ae-
dc.contributor.affiliatedAuthor강신애-
dc.contributor.affiliatedAuthor김경래-
dc.contributor.affiliatedAuthor김경래-
dc.contributor.affiliatedAuthor김민경-
dc.contributor.affiliatedAuthor김민경-
dc.contributor.affiliatedAuthor박종숙-
dc.contributor.affiliatedAuthor박종숙-
dc.contributor.affiliatedAuthor안철우-
dc.contributor.affiliatedAuthor안철우-
dc.contributor.affiliatedAuthor유지홍-
dc.contributor.affiliatedAuthor유지홍-
dc.contributor.affiliatedAuthor이민영-
dc.contributor.affiliatedAuthor이민영-
dc.citation.volume34-
dc.citation.number5-
dc.citation.startPage1068-
dc.citation.endPage1077-
dc.identifier.bibliographicCitationKorean Journal of Internal Medicine, Vol.34(5) : 1068-1077, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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