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Short- and long-term seizure-free outcomes of dietary treatment in infants according to etiology

DC Field Value Language
dc.contributor.author강훈철-
dc.contributor.author김세희-
dc.contributor.author김흥동-
dc.contributor.author이준수-
dc.contributor.author고아라-
dc.date.accessioned2019-10-28T01:51:42Z-
dc.date.available2019-10-28T01:51:42Z-
dc.date.issued2019-
dc.identifier.issn1059-1311-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171370-
dc.description.abstractPURPOSE: It is important to determine whether specific etiology is more effective to dietary treatment so that the diet can be started earlier for infants. We evaluated etiology-specific, seizure-free outcomes of dietary treatment in infants <1 year of age. METHODS: We conducted a 10-year, retrospective, longitudinal observational study of 115 infants treated with ketogenic diet (KD) or modified Atkins diet (MAD). RESULTS: Most patients (70%) received classical KD; 30% received MAD. During follow-up, 90%, 73%, and 61% of the patients remained on the diet at 3, 6, and 12 months, respectively. Seizure-free outcomes were reported in 50%, 44%, and 50% of the patients at 3, 6, and 12 months, respectively. Long-term seizure-free outcomes over 12 months were reported in 43 (74%) of 58 infants who were seizure-free at 3 months. Etiologies were mostly symptomatic (structural brain abnormalities, genetic, or metabolic) in 83 (72%) of 115 patients. According to underlying etiology, long-term seizure-free outcomes were observed in 14 (33%) of 42 patients with structural brain abnormalities, 7 (33%) of 21 with genetic etiologies, 7 (35%) of 20 with metabolic etiologies, and 15 (47%) of 32 with unknown etiologies. There were no etiology-based differences with respect to long-term seizure-free outcomes (P = 0.63). CONCLUSION: The high rate of long-term seizure-free outcomes can be predicted based on the seizure freedom at 3 months regardless of etiology. Early dietary treatment is beneficial, even in infants <1 year of age with specific symptomatic etiologies such as genetic, structural brain abnormalities, and metabolic etiology.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfSeizure - European Journal of Epilepsy-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleShort- and long-term seizure-free outcomes of dietary treatment in infants according to etiology-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorIgam Riantarini-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorAra Ko-
dc.contributor.googleauthorSe Hee Kim-
dc.contributor.googleauthorHoon-Chul Kang-
dc.contributor.googleauthorJoon Soo Lee-
dc.contributor.googleauthorDa Eun Jung-
dc.identifier.doi10.1016/j.seizure.2019.06.002-
dc.contributor.localIdA00102-
dc.contributor.localIdA00611-
dc.contributor.localIdA01208-
dc.contributor.localIdA03177-
dc.relation.journalcodeJ02648-
dc.identifier.eissn1532-2688-
dc.identifier.pmid31252281-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1059131118307817-
dc.subject.keywordEtiology-
dc.subject.keywordInfants-
dc.subject.keywordKetogenic diet-
dc.subject.keywordModified Atkins diet-
dc.subject.keywordSeizure-free-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.contributor.affiliatedAuthor강훈철-
dc.contributor.affiliatedAuthor김세희-
dc.contributor.affiliatedAuthor김흥동-
dc.contributor.affiliatedAuthor이준수-
dc.citation.volume71-
dc.citation.startPage100-
dc.citation.endPage104-
dc.identifier.bibliographicCitationSeizure - European Journal of Epilepsy, Vol.71 : 100-104, 2019-
dc.identifier.rimsid63750-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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