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Development of a Shape-Memory Tube to Prevent Vascular Stenosis

 Yong Cheol Shin  ;  Jung Bok Lee  ;  Dae‐Hyun Kim  ;  Taeyoung Kim  ;  Grant Alexander  ;  Young Min Shin  ;  Ju Young Park  ;  Sewoom Baek  ;  Jeong‐Kee Yoon  ;  Yong Jae Lee  ;  Gyeung Mi Seon  ;  Mi Hee Lee  ;  Mi‐Lan Kang  ;  Woo Soon Jang  ;  Jong‐Chul Park  ;  Ho‐Wook Jun  ;  YongTae Kim  ;  Hak‐Joon Sung 
 Advanced Materials, Vol.31(41) : e1904476, 2019 
Journal Title
 Advanced Materials 
Issue Date
computational fluid dynamics ; nitric oxide-releasing peptide ; shape memory polymer ; vascular graft ; vascular remodeling
Inserting a graft into vessels with different diameters frequently causes severe damage to the host vessels. Poor flow patency is an unresolved issue in grafts, particularly those with diameters less than 6 mm, because of vessel occlusion caused by disturbed blood flow following fast clotting. Herein, successful patency in the deployment of an ≈2 mm diameter graft into a porcine vessel is reported. A new library of property-tunable shape-memory polymers that prevent vessel damage by expanding the graft diameter circumferentially upon implantation is presented. The polymers undergo seven consecutive cycles of strain energy-preserved shape programming. Moreover, the new graft tube, which features a diffuser shape, minimizes disturbed flow formation and prevents thrombosis because its surface is coated with nitric-oxide-releasing peptides. Improved patency in a porcine vessel for 18 d is demonstrated while occlusive vascular remodeling occurs. These insights will help advance vascular graft design.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae-Hyun(김대현)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
Shin, Yong Cheol(신용철)
Yoon, Jeong-Kee(윤정기) ORCID logo https://orcid.org/0000-0003-0111-9911
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
Lee, Yong Jae(이용재) ORCID logo https://orcid.org/0000-0003-0297-3116
Lee, Jung Bok(이정복) ORCID logo https://orcid.org/0000-0001-9227-2027
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