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miR-374a-5p promotes tumor progression by targeting ARRB1 in triple negative breast cancer

DC FieldValueLanguage
dc.contributor.author강혁구-
dc.contributor.author전경희-
dc.date.accessioned2019-10-28T01:48:07Z-
dc.date.available2019-10-28T01:48:07Z-
dc.date.issued2019-
dc.identifier.issn0304-3835-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171344-
dc.description.abstractTriple negative breast cancer (TNBC) has higher aggressiveness and poorer outcomes compared with other subtypes of breast cancer. However, the genomic and molecular aberrations of TNBC are largely unknown. In this study, miR-374a-5p was discovered as a novel TNBC-specific miRNA and its functions and the molecular mechanisms involved were investigated. Combined gene expression profiling of miRNA-microarray and human transcriptome dataset analysis revealed that miR-374a-5p is specifically upregulated in TNBC patients. Functional studies using in vitro and in vivo models indicated that upregulated miR-374a-5p promotes tumor progression in TNBC. miR-374a-5p was also found to directly target arrestin beta 1 (ARRB1) that is specifically downregulated in TNBC patients in several human genomic datasets. Overexpressed ARRB1 reduced TNBC cell growth and migration, and the ARRB1 expression level is inversely correlated with the histological grade of the breast cancer and positively associated with TNBC patient survival, suggestive of a tumor-suppressive function of ARRB1 in breast cancer. Interestingly, increased ARRB1 activates AMPK in TNBC cells, associated with the expression of miR-374a-5p. Taken together, the findings suggest that miR-374a-5p is a potential prognostic marker of TNBC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science Ireland-
dc.relation.isPartOfCancer Letters-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlemiR-374a-5p promotes tumor progression by targeting ARRB1 in triple negative breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.googleauthorDasom Son-
dc.contributor.googleauthorYesol Kim-
dc.contributor.googleauthorSera Lim-
dc.contributor.googleauthorHyeok-Gu Kang-
dc.contributor.googleauthorDa-Hyun Kim-
dc.contributor.googleauthorJee Won Park-
dc.contributor.googleauthorWoosung Cheong-
dc.contributor.googleauthorHyun Kyung Kong-
dc.contributor.googleauthorWonshik Han-
dc.contributor.googleauthorWoong-Yang Park-
dc.contributor.googleauthorKyung-Hee Chun-
dc.contributor.googleauthorJong Hoon Park-
dc.identifier.doi10.1016/j.canlet.2019.04.006-
dc.contributor.localIdA00090-
dc.contributor.localIdA03501-
dc.contributor.localIdA03501-
dc.relation.journalcodeJ00448-
dc.identifier.eissn1872-7980-
dc.identifier.pmid31004703-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0304383519302319-
dc.subject.keywordAMPKα-
dc.subject.keywordArrestin beta 1-
dc.subject.keywordTriple negative breast cancer-
dc.subject.keywordmiR-374a-5p-
dc.contributor.alternativeNameKang, Hyeok Gu-
dc.contributor.affiliatedAuthor강혁구-
dc.contributor.affiliatedAuthor전경희-
dc.contributor.affiliatedAuthor전경희-
dc.citation.volume454-
dc.citation.startPage224-
dc.citation.endPage233-
dc.identifier.bibliographicCitationCancer Letters, Vol.454 : 224-233, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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