63 65

Cited 2 times in

Radiation-Induced CXCL12 Upregulation via Histone Modification at the Promoter in the Tumor Microenvironment of Hepatocellular Carcinoma

DC FieldValueLanguage
dc.contributor.author성진실-
dc.contributor.author이은정-
dc.contributor.author이익재-
dc.date.accessioned2019-10-28T01:47:59Z-
dc.date.available2019-10-28T01:47:59Z-
dc.date.issued2019-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171343-
dc.description.abstractTumor cells can vary epigenetically during ionizing irradiation (IR) treatment. These epigenetic variegations can influence IR response and shape tumor aggressiveness. However, epigenetic disturbance of histones after IR, implicating in IR responsiveness, has been elusive. Here, we investigate whether altered histone modification after IR can influence radiation responsiveness. The oncogenic CXCL12 mRNA and protein were more highly expressed in residual cancer cells from a hepatoma heterotopic murine tumor microenvironment and coculture of human hepatoma Huh7 and normal IMR90 cells after radiation. H3K4 methylation was also enriched and H3K9 methylation was decreased at its promoter region. Accordingly, invasiveness and the subpopulation of aggressive CD133+/CD24- cells increased after IR. Histone demethylase inhibitor IOX1 attenuated CXCL12 expression and the malignant subpopulation, suggesting that responses to IR can be partially mediated via histone modifications. Taken together, radiation-induced histone alterations at the CXCL12 promoter in hepatoma cells are linked to CXCL12 upregulation and increased aggressiveness in the tumor microenvironment.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Molecular and Cellular Biology-
dc.relation.isPartOfMolecules and Cells-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleRadiation-Induced CXCL12 Upregulation via Histone Modification at the Promoter in the Tumor Microenvironment of Hepatocellular Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorHak Jun Ahn-
dc.contributor.googleauthorSoon Young Hwang-
dc.contributor.googleauthorNgoc Hoan Nguyen-
dc.contributor.googleauthorIk Jae Lee-
dc.contributor.googleauthorEun Jeong Lee-
dc.contributor.googleauthorJinsil Seong-
dc.contributor.googleauthorJong-Soo Lee-
dc.identifier.doi10.14348/molcells.2019.2280-
dc.contributor.localIdA01956-
dc.contributor.localIdA03047-
dc.contributor.localIdA03047-
dc.contributor.localIdA03055-
dc.contributor.localIdA03055-
dc.relation.journalcodeJ02273-
dc.identifier.eissn0219-1032-
dc.identifier.pmid31362469-
dc.subject.keywordCXCL12-
dc.subject.keywordhistone modification-
dc.subject.keywordmalignancy-
dc.subject.keywordradiation-
dc.subject.keywordtumor microenvironment-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.affiliatedAuthor성진실-
dc.contributor.affiliatedAuthor이은정-
dc.contributor.affiliatedAuthor이은정-
dc.contributor.affiliatedAuthor이익재-
dc.contributor.affiliatedAuthor이익재-
dc.citation.volume42-
dc.citation.number7-
dc.citation.startPage530-
dc.citation.endPage545-
dc.identifier.bibliographicCitationMolecules and Cells, Vol.42(7) : 530-545, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.