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Value of controlled attenuation parameter in fibrosis prediction in nonalcoholic steatohepatitis

DC FieldValueLanguage
dc.contributor.author이관식-
dc.contributor.author이정일-
dc.contributor.author이현웅-
dc.date.accessioned2019-10-28T01:47:01Z-
dc.date.available2019-10-28T01:47:01Z-
dc.date.issued2019-
dc.identifier.issn1007-9327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171334-
dc.description.abstractBACKGROUND: Liver stiffness measurement (LSM) tends to overestimate fibrosis stage in nonalcoholic fatty liver disease (NAFLD). Controlled attenuation parameter (CAP), provided by LSM device, has been introduced for noninvasive quantification of hepatic steatosis. AIM: To determine the role of CAP values in predicting liver fibrosis stage by LSM in nonalcoholic steatohepatitis (NASH). METHODS: One hundred eighty-four patients with biopsy proven NASH had LSM and CAP evaluated at baseline. Among them, 130 patients had 1-year follow up LSM and analyzed for the changes of LSM after pioglitazone or ursodeoxycholic acid (UDCA) treatment. RESULTS: In Kleiner fibrosis stage F0-1, LSM values increased at higher CAP tertile (P = 0.001), and in F2, at middle and higher tertiles (P = 0.027). No difference across CAP tertiles was noticed in F3-4 (P = 0.752). Receiver operating characteristic curve for LSM cutoff in diagnosis of F ≥ 2 identified 8.05 kPa for lower CAP tertile, 9.35 kPa for middle, and 10.55 kPa for high tertile. When changes in proportion of significant fibrosis (F ≥ 2) were assessed among pioglitazone and UDCA treated patients considering CAP values, pioglitazone treated patients demonstrated decrease in proportion of high LSM. CONCLUSION: In patient with NAFLD, interpretation of LSM in association with CAP scores may provide helpful information sparing unnecessary liver biopsy.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBaishideng Publishing Group-
dc.relation.isPartOfWorld Journal of Gastroenterology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleValue of controlled attenuation parameter in fibrosis prediction in nonalcoholic steatohepatitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJung Il Lee-
dc.contributor.googleauthorHyun Woong Lee-
dc.contributor.googleauthorKwan Sik Lee-
dc.identifier.doi10.3748/wjg.v25.i33.4959-
dc.contributor.localIdA02666-
dc.contributor.localIdA03122-
dc.contributor.localIdA03122-
dc.contributor.localIdA03292-
dc.contributor.localIdA03292-
dc.relation.journalcodeJ02795-
dc.identifier.eissn2219-2840-
dc.identifier.pmid31543686-
dc.subject.keywordControlled attenuation parameter-
dc.subject.keywordFibroscan-
dc.subject.keywordLiver fibrosis-
dc.subject.keywordLiver stiffness-
dc.subject.keywordNonalcoholic steatohepatitis-
dc.contributor.alternativeNameLee, Kwan Sik-
dc.contributor.affiliatedAuthor이관식-
dc.contributor.affiliatedAuthor이정일-
dc.contributor.affiliatedAuthor이정일-
dc.contributor.affiliatedAuthor이현웅-
dc.contributor.affiliatedAuthor이현웅-
dc.citation.volume25-
dc.citation.number33-
dc.citation.startPage4959-
dc.citation.endPage4969-
dc.identifier.bibliographicCitationWorld Journal of Gastroenterology, Vol.25(33) : 4959-4969, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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