Cited 9 times in
Serum Alkaline Phosphatase as a Predictor of Cardiac and Cerebrovascular Complications after Lumbar Spinal Fusion Surgery in Elderly: A Retrospective Study
DC Field | Value | Language |
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dc.contributor.author | 송영 | - |
dc.contributor.author | 한동우 | - |
dc.contributor.author | 함성연 | - |
dc.date.accessioned | 2019-10-28T01:35:09Z | - |
dc.date.available | 2019-10-28T01:35:09Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171259 | - |
dc.description.abstract | We retrospectively enrolled 1395 patients aged > 65 years undergoing posterior lumbar spinal fusion surgery and classified them into tertiles based on serum Alkaline Phosphatase (ALP) levels (<63, 63-79, >79 IU/L). The primary outcome was the incidence of 30-day major adverse cardiac and cerebrovascular events (MACCE; composite endpoint defined as the occurrence of ≥1 of the following events: new-onset myocardial infarction, stroke, or cardiovascular mortality). The incidence of the composite endpoint was the highest in the third serum ALP tertile (0.4% vs. 0.2% vs. 2.2% in the first, second, and third tertile, respectively, p = 0.003). Multivariate analysis showed that the third serum ALP tertile was an independent predictor of the composite endpoint of MACCE (odds ratio 4.507, 95% confidence interval 1.378-14.739, p = 0.013). The optimal cut-off value of preoperative serum ALP showing the best discriminatory capacity to predict postoperative MACCE (measured by receiver-operating characteristic curve analysis) was 83 IU/L (area under curve 0.694, 95% confidence interval 0.574-0.813, p = 0.016). Preoperative serum ALP levels were independently associated with the composite endpoint of postoperative 30-days MACCE. We suggest that serum ALP can be used as a biomarker to predict cardiac and cerebrovascular complications following lumbar spinal fusion surgery in elderly patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Journal of Clinical Medicine | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Serum Alkaline Phosphatase as a Predictor of Cardiac and Cerebrovascular Complications after Lumbar Spinal Fusion Surgery in Elderly: A Retrospective Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Ann Hee You | - |
dc.contributor.googleauthor | Dong Woo Han | - |
dc.contributor.googleauthor | Sung Yeon Ham | - |
dc.contributor.googleauthor | Wonsik Lim | - |
dc.contributor.googleauthor | Young Song | - |
dc.identifier.doi | 10.3390/jcm8081111 | - |
dc.contributor.localId | A02036 | - |
dc.contributor.localId | A04274 | - |
dc.contributor.localId | A05192 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 31357535 | - |
dc.subject.keyword | alkaline phosphatase | - |
dc.subject.keyword | elderly | - |
dc.subject.keyword | postoperative complication | - |
dc.contributor.alternativeName | Song, Young | - |
dc.contributor.affiliatedAuthor | 송영 | - |
dc.contributor.affiliatedAuthor | 한동우 | - |
dc.contributor.affiliatedAuthor | 함성연 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | E1111 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Medicine, Vol.8(8) : E1111, 2019 | - |
dc.identifier.rimsid | 63947 | - |
dc.type.rims | ART | - |
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