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Serum cystatin C level: An excellent predictor of mortality in patients with cirrhotic ascites

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dc.contributor.author박준용-
dc.date.accessioned2019-10-28T01:29:18Z-
dc.date.available2019-10-28T01:29:18Z-
dc.date.issued2018-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171221-
dc.description.abstractBACKGROUND AND AIM: Although serum cystatin C level is considered a more accurate marker of renal function in patients with liver cirrhosis, its prognostic efficacy remains uncertain. This study aimed to evaluate the prognostic efficacy of serum cystatin C level in patients with cirrhotic ascites. METHODS: Patients with cirrhotic ascites from 15 hospitals were prospectively enrolled between September 2009 and March 2013. Cox regression analyses were performed to identify independent predictive factors of mortality and development of type 1 hepatorenal syndrome (HRS-1). RESULTS: In total, 350 patients were enrolled in this study. The mean age was 55.4 ± 10.8 years, and 267 patients (76.3%) were men. The leading cause of liver cirrhosis was alcoholic liver disease (64.3%), followed by chronic viral hepatitis (29.7%). Serum creatinine and cystatin C levels were 0.9 ± 0.4 mg/dL and 1.1 ± 0.5 mg/L, respectively. Multivariate analyses revealed that international normalized ratio and serum bilirubin, sodium, and cystatin C levels were independent predictors of mortality and international normalized ratio and serum sodium and cystatin C levels were independent predictors of the development of HRS-1. Serum creatinine level was not significantly associated with mortality and development of HRS-1 on multivariate analysis. CONCLUSION: Serum cystatin C level was an independent predictor of mortality and development of HRS-1 in patients with cirrhotic ascites, while serum creatinine level was not. Predictive models based on serum cystatin C level instead of serum creatinine level would be more helpful in the assessment of the condition and prognosis of patients with cirrhotic ascites.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Scientific Publications-
dc.relation.isPartOfJournal of Gastroenterology and Hepatology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAscites/diagnosis*-
dc.subject.MESHAscites/etiology-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHCystatin C/blood*-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis, Viral, Human/complications-
dc.subject.MESHHepatorenal Syndrome/etiology-
dc.subject.MESHHumans-
dc.subject.MESHLiver Cirrhosis/diagnosis*-
dc.subject.MESHLiver Cirrhosis/etiology-
dc.subject.MESHLiver Diseases, Alcoholic/complications-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.titleSerum cystatin C level: An excellent predictor of mortality in patients with cirrhotic ascites-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYeon Seok Seo-
dc.contributor.googleauthorSoo Young Park-
dc.contributor.googleauthorMoon Young Kim-
dc.contributor.googleauthorSang Gyune Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorHyung Joon Yim-
dc.contributor.googleauthorByoung Kuk Jang-
dc.contributor.googleauthorSeung Ha Park-
dc.contributor.googleauthorJi Hoon Kim-
dc.contributor.googleauthorKi Tae Suk-
dc.contributor.googleauthorJin Dong Kim-
dc.contributor.googleauthorTae Yeob Kim-
dc.contributor.googleauthorEun Young Cho-
dc.contributor.googleauthorJun Sung Lee-
dc.contributor.googleauthorSoung Won Jung-
dc.contributor.googleauthorJae Young Jang-
dc.contributor.googleauthorHyonggin An-
dc.contributor.googleauthorWon Young Tak-
dc.contributor.googleauthorSoon Koo Baik-
dc.contributor.googleauthorJae Seok Hwang-
dc.contributor.googleauthorYoung Seok Kim-
dc.contributor.googleauthorJoo Hyun Sohn-
dc.contributor.googleauthorSoon Ho Um-
dc.identifier.doi10.1111/jgh.13983-
dc.contributor.localIdA01675-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid28910501-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/jgh.13983-
dc.subject.keywordcreatinine-
dc.subject.keywordcystatin C-
dc.subject.keywordhepatorenal syndrome-
dc.subject.keywordliver cirrhosis-
dc.subject.keywordrenal dysfunction-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.affiliatedAuthor박준용-
dc.citation.volume33-
dc.citation.number4-
dc.citation.startPage910-
dc.citation.endPage917-
dc.identifier.bibliographicCitationJournal of Gastroenterology and Hepatology, Vol.33(4) : 910-917, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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