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Reduction Rate of Specific IgE Level as a Predictor of Persistent Egg Allergy in Children

DC Field Value Language
dc.contributor.author김경원-
dc.contributor.author김민정-
dc.contributor.author김수연-
dc.contributor.author김윤희-
dc.contributor.author손명현-
dc.contributor.author김종덕-
dc.contributor.author설인숙-
dc.date.accessioned2019-09-20T08:03:37Z-
dc.date.available2019-09-20T08:03:37Z-
dc.date.issued2019-
dc.identifier.issn2092-7355-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171180-
dc.description.abstractPURPOSE: Egg is the most common food allergen in infants. However, the natural course of egg allergy has not been fully elucidated. This study aimed to describe clinical characteristics and to identify prognostic factors associated with tolerance acquisition of immunoglobulin E (IgE)-mediated egg allergy in children. METHODS: Children who underwent more than 1 follow-up egg white-specific immunoglobulin E (EWsIgE) test between November 2005 and November 2015 at -Severance Children's Hospital were assessed. Children were diagnosed as having IgE-mediated egg allergy based on immediate allergic reaction after egg consumption and an EWsIgE level of > 0.35 kU/L. The children were divided into "tolerant" and "persistent" groups according to tolerance acquisition defined as egg consumption without adverse allergic reactions. RESULTS: Of 124 participants, egg allergy resolved in 101 (81.5%) children. The persistent group had more atopic dermatitis (P = 0.039), and more wheat (P = 0.009) and peanut (P = 0.012) allergies compared to the tolerant group. The EWsIgE levels at diagnosis (EWsIgEdiag) were higher in the persistent group than in the tolerant group (P = 0.001). The trend of the EWsIgE levels in the tolerant group decreased markedly over time compared to the persistent group (P < 0.001). In predicting egg allergy tolerance acquisition, the reduction rate of EWsIgE level after 12 months from diagnosis (ΔEWsIgE12mo) tended to be more accurate than EWsIgEdiag (area under the curve: 0.835 vs. 0.731). When ΔEWsIgE12mo was ≥ 30%, tolerance acquisition was more frequent than that of < 30% (91.9% vs. 57.9%; P < 0.001). CONCLUSIONS: ΔEWsIgE12mo can be used as an early independent predictor of tolerance acquisition of IgE-mediated egg allergy in children.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.publisherKorean Academy of Pediatric Allergy and Respiratory Disease-
dc.relation.isPartOfAllergy Asthma & Immunology Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleReduction Rate of Specific IgE Level as a Predictor of Persistent Egg Allergy in Children-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorJong Deok Kim-
dc.contributor.googleauthorSoo Yeon Kim-
dc.contributor.googleauthorEun Ji Kwak-
dc.contributor.googleauthorIn Suk Sol-
dc.contributor.googleauthorMin Jung Kim-
dc.contributor.googleauthorYoon Hee Kim-
dc.contributor.googleauthorKyung Won Kim-
dc.contributor.googleauthorMyung Hyun Sohn-
dc.identifier.doi10.4168/aair.2019.11.4.498-
dc.contributor.localIdA00303-
dc.contributor.localIdA00472-
dc.contributor.localIdA04724-
dc.contributor.localIdA00799-
dc.contributor.localIdA01967-
dc.relation.journalcodeJ00064-
dc.identifier.eissn2092-7363-
dc.identifier.pmid31172718-
dc.subject.keywordEgg hypersensitivity-
dc.subject.keywordchild-
dc.subject.keywordegg white-
dc.subject.keywordfood allergy-
dc.subject.keywordimmunoglobulin E-
dc.contributor.alternativeNameKim, Kyung Won-
dc.contributor.affiliatedAuthor김경원-
dc.contributor.affiliatedAuthor김민정-
dc.contributor.affiliatedAuthor김수연-
dc.contributor.affiliatedAuthor김윤희-
dc.contributor.affiliatedAuthor손명현-
dc.citation.volume11-
dc.citation.number4-
dc.citation.startPage498-
dc.citation.endPage507-
dc.identifier.bibliographicCitationAllergy Asthma & Immunology Research, Vol.11(4) : 498-507, 2019-
dc.identifier.rimsid63308-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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