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Prediction of biochemical failure using prostate-specific antigen half-life in patients with adverse pathologic features after radical prostatectomy
DC Field | Value | Language |
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dc.contributor.author | 구교철 | - |
dc.contributor.author | 이광석 | - |
dc.contributor.author | 정병하 | - |
dc.date.accessioned | 2019-09-20T08:02:05Z | - |
dc.date.available | 2019-09-20T08:02:05Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0724-4983 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171173 | - |
dc.description.abstract | PURPOSE: Prostate-specific antigen nadir and time to prostate-specific antigen nadir are predictors of disease progression in patients who undergo radical prostatectomy. However, a mutually conflicting relationship exists between them. Thus, we compared postoperative prostate-specific antigen levels at the first follow-up with the expected levels while considering the half-life of prostate-specific antigen to improve the prediction of biochemical failure after radical prostatectomy in patients with adverse pathologic features. METHODS: Patients treated with robot-assisted laparoscopic prostatectomy were enrolled. Patients with a follow-up duration of < 12 months or positive lymphadenectomy results were excluded. "Adverse prostate-specific antigen" was defined as a prostate-specific antigen level higher than the expected level at 6 weeks. RESULTS: Among 450 patients, adverse pathologic features and adverse prostate-specific antigen were found in 260 (57.8%) and 245 (54.5%) patients, respectively. Analysis of patients with and without abnormal prostate-specific antigen level revealed significantly different biochemical failure-free survival outcomes. Patients with one adverse pathologic feature but without adverse prostate-specific antigen showed similar biochemical failure-free survival to those without adverse pathologic features. Adverse prostate-specific antigen was identified as an independent predictor for biochemical failure within 1 year after radical prostatectomy. The area under the curve when adding adverse prostate-specific antigen to the conventional factors was significantly higher than that for the conventional factors alone. CONCLUSION: The difference between postoperative prostate-specific antigen levels at the first follow-up visit after radical prostatectomy and the expected level while considering the half-life of prostate-specific antigen is a predictive factor for treatment efficacy following radical prostatectomy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | World Journal of Urology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Prediction of biochemical failure using prostate-specific antigen half-life in patients with adverse pathologic features after radical prostatectomy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Kwang Suk Lee | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.identifier.doi | 10.1007/s00345-018-2531-0 | - |
dc.contributor.localId | A00188 | - |
dc.contributor.localId | A02668 | - |
dc.contributor.localId | A03607 | - |
dc.relation.journalcode | J02805 | - |
dc.identifier.eissn | 1433-8726 | - |
dc.identifier.pmid | 30350018 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00345-018-2531-0 | - |
dc.subject.keyword | Patient outcome assessment | - |
dc.subject.keyword | Prostate | - |
dc.subject.keyword | Prostate cancer | - |
dc.subject.keyword | Prostatectomy | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | 구교철 | - |
dc.contributor.affiliatedAuthor | 이광석 | - |
dc.contributor.affiliatedAuthor | 정병하 | - |
dc.citation.volume | 37 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1321 | - |
dc.citation.endPage | 1328 | - |
dc.identifier.bibliographicCitation | World Journal of Urology, Vol.37(7) : 1321-1328, 2019 | - |
dc.identifier.rimsid | 64110 | - |
dc.type.rims | ART | - |
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