Cited 10 times in
Association of Vitamin D with Inflammatory Bowel Disease Activity in Pediatric Patients
DC Field | Value | Language |
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dc.contributor.author | 고홍 | - |
dc.contributor.author | 김서영 | - |
dc.contributor.author | 김승 | - |
dc.contributor.author | 박소원 | - |
dc.contributor.author | 강윤구 | - |
dc.date.accessioned | 2019-09-20T07:59:21Z | - |
dc.date.available | 2019-09-20T07:59:21Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171153 | - |
dc.description.abstract | BACKGROUND: It has been known that vitamin D level (serum 25[OH]D) has correlation with inflammatory bowel disease (IBD). The purpose of this study is to investigate changes of serum 25[OH]D in pediatric IBD patients according to the disease activity. METHODS: A total of 96 children and adolescent with IBD were enrolled in this retrospective study. Serologic inflammatory markers and clinical disease activity scores of the patients were collected, and their correlations with serum 25[OH]D were analyzed. Seasonal variations of serum 25[OH]D were also investigated both in active disease state and remission state. RESULTS: Of the 96 patients, 41 (43%) were women and patients with a vitamin D deficiency (< 20 ng/mL) at diagnosis were 77 (80.2%). There was no significant difference between Crohn's disease and ulcerative colitis for serum 25[OH]D. Serum 25[OH]D was higher in remission group than in active disease group (12.4 [8.8-29] ng/mL vs. 17.9 [12.3-34.4] ng/mL; P < 0.001) and the difference was more significant than other micronutrients. There was no significant difference in serum 25[OH]D concentration between patients with ileal involvement and patients without ileal involvement. There were seasonal variations in the active phase, but there was no significant difference by season in the remission phase. CONCLUSION: Serum 25[OH]D is inversely correlated with disease activity in IBD. Monitoring and supplementation is required especially for active disease status and in winter and spring season. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | Journal of Korean Medical Science | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association of Vitamin D with Inflammatory Bowel Disease Activity in Pediatric Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Seoyoung Kim | - |
dc.contributor.googleauthor | Yunkoo Kang | - |
dc.contributor.googleauthor | Sowon Park | - |
dc.contributor.googleauthor | Hong Koh | - |
dc.contributor.googleauthor | Seung Kim | - |
dc.identifier.doi | 10.3346/jkms.2019.34.e204 | - |
dc.contributor.localId | A00156 | - |
dc.contributor.localId | A05750 | - |
dc.contributor.localId | A00651 | - |
dc.contributor.localId | A05216 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 31432649 | - |
dc.subject.keyword | Crohn's Disease | - |
dc.subject.keyword | Disease Activity | - |
dc.subject.keyword | Inflammatory Bowel Disease | - |
dc.subject.keyword | Pediatric | - |
dc.subject.keyword | Ulcerative Colitis | - |
dc.subject.keyword | Vitamin D | - |
dc.contributor.alternativeName | Koh, Hong | - |
dc.contributor.affiliatedAuthor | 고홍 | - |
dc.contributor.affiliatedAuthor | 김서영 | - |
dc.contributor.affiliatedAuthor | 김승 | - |
dc.contributor.affiliatedAuthor | 박소원 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 32 | - |
dc.citation.startPage | e204 | - |
dc.identifier.bibliographicCitation | Journal of Korean Medical Science, Vol.34(32) : e204, 2019 | - |
dc.identifier.rimsid | 63892 | - |
dc.type.rims | ART | - |
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