Cited 11 times in
Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis
DC Field | Value | Language |
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dc.contributor.author | 김동수 | - |
dc.contributor.author | 신재일 | - |
dc.contributor.author | 이금화 | - |
dc.contributor.author | 채현욱 | - |
dc.date.accessioned | 2019-09-20T07:59:00Z | - |
dc.date.available | 2019-09-20T07:59:00Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0278-0240 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171150 | - |
dc.description.abstract | Introduction: Matrix metalloproteinase (MMP) is an emerging disease marker in rheumatic diseases. This is a meta-analysis aimed at systematically reviewing association between serum MMP-3 levels and systematic lupus erythematosus (SLE) activity, which sought to raise interest in MMP-3 as a putative biomarker. Methods: We conducted a meta-analysis of serum MMP-3 levels in patients with SLE and controls. We performed a PubMed search, EMBASE search, and forward search of the retrieved articles published until Oct. 1, 2018. In addition to this, we included data from a case-control study on a national pediatric SLE cohort, in which serum MMP-3 levels were measured in 11 SLE patients and 9 controls (unpublished). Subgroup analyses based on gender and disease activity were performed. Results: A total of 662 cases and 771 controls including 651 patients and 762 controls from 11 publications were studied. We observed significantly higher MMP-3 levels in SLE patients compared to healthy controls (P < 0.001, Hedges' g: 2.104, 95% CI 1.426-2.782). In subgroup analyses, we found a significant elevation of MMP-3 in the patients with nephritis compared to those without (P = 0.006, Hedges' g: 0.611, 95% CI 0.611-1.704). This finding was consistent between patients with persistent proteinuria and those without (P = 0.023, Hedges' g: 1.535, 95% CI 0.207-2.862). Meta-analysis showed no association between MMP-3 levels and gender or anti-double strand DNA antibody titer. Conclusions: Our meta-analysis demonstrated significantly higher MMP-3 levels in SLE patients than in controls and in patients with renal involvement than in those without. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Hindawi Pub. Corp. | - |
dc.relation.isPartOf | Disease Markers | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Jiwon M. Lee | - |
dc.contributor.googleauthor | Andreas Kronbichler | - |
dc.contributor.googleauthor | Se Jin Park | - |
dc.contributor.googleauthor | Seong Heon Kim | - |
dc.contributor.googleauthor | Kyoung Hee Han | - |
dc.contributor.googleauthor | Hee Gyung Kang | - |
dc.contributor.googleauthor | Il Soo Ha | - |
dc.contributor.googleauthor | Hae Il Cheong | - |
dc.contributor.googleauthor | Ki Hwan Kim | - |
dc.contributor.googleauthor | Gaeun Kim | - |
dc.contributor.googleauthor | Dong Soo Kim | - |
dc.contributor.googleauthor | Hyun Wook Chae | - |
dc.contributor.googleauthor | Chul Ho Lee | - |
dc.contributor.googleauthor | Keum Hwa Lee | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.identifier.doi | 10.1155/2019/9796735 | - |
dc.contributor.localId | A00405 | - |
dc.contributor.localId | A02142 | - |
dc.contributor.localId | A04622 | - |
dc.contributor.localId | A04026 | - |
dc.relation.journalcode | J00743 | - |
dc.identifier.eissn | 1875-8630 | - |
dc.identifier.pmid | 31396295 | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.affiliatedAuthor | 김동수 | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.contributor.affiliatedAuthor | 이금화 | - |
dc.contributor.affiliatedAuthor | 채현욱 | - |
dc.citation.volume | 2019 | - |
dc.citation.startPage | 9796735 | - |
dc.identifier.bibliographicCitation | Disease Markers, Vol.2019 : 9796735, 2019 | - |
dc.identifier.rimsid | 64045 | - |
dc.type.rims | ART | - |
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