Cited 35 times in
Oxaliplatin-loaded chemically cross-linked hydrogels for prevention of postoperative abdominal adhesion and colorectal cancer therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박은정 | - |
dc.contributor.author | 백승혁 | - |
dc.contributor.author | 전영배 | - |
dc.date.accessioned | 2019-09-20T07:55:39Z | - |
dc.date.available | 2019-09-20T07:55:39Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171122 | - |
dc.description.abstract | Colorectal cancer (CRC) is the third most commonly diagnosed cancer among both men and women worldwide. New therapeutic strategies involving cytoreductive surgery and intra-peritoneal chemotherapy could lead to a definitive cure in some cases. However, postoperative intra-abdominal adhesion can cause further complications. In this study, hyaluronic acid (HA)- and carboxymethyl cellulose sodium (CMCNa)-based novel cross-linked hydrogels (HC hydrogels) were synthesized and fully characterized. We demonstrated that varied compositions of HA and CMCNa altered the microstructure, rheology, and degradation behavior of hydrogels. Pre-constructed hydrogels were further loaded with oxaliplatin to prevent intra-abdominal adhesion following chemotherapy. Sustained release of oxaliplatin was observed from hydrogels compared that from solutions, which release drugs through diffusion, following the Higuchi and Korsmeyer-Peppas models. Moreover, low adhesion scores in an in vivo SD rat model demonstrated inhibition of intra-peritoneal adhesion in response to HC hydrogels. Therefore, HC hydrogels offer a novel formulation strategy for providing an intra-abdominal anti-adhesion barrier after cytoreductive surgery and intra-peritoneal chemotherapy for CRC treatment. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier/North-Holland Biomedical Press. | - |
dc.relation.isPartOf | International Journal of Pharmaceutics | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Oxaliplatin-loaded chemically cross-linked hydrogels for prevention of postoperative abdominal adhesion and colorectal cancer therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Jee Eun Lee | - |
dc.contributor.googleauthor | Sharif Md Abuzar | - |
dc.contributor.googleauthor | Yeji Seo | - |
dc.contributor.googleauthor | Hyeji Han | - |
dc.contributor.googleauthor | Youngbae Jeon | - |
dc.contributor.googleauthor | Eun Jung Park | - |
dc.contributor.googleauthor | Seung Hyuk Baik | - |
dc.contributor.googleauthor | Sung-Joo Hwang | - |
dc.identifier.doi | 10.1016/j.ijpharm.2019.04.065 | - |
dc.contributor.localId | A04572 | - |
dc.contributor.localId | A01827 | - |
dc.contributor.localId | A05767 | - |
dc.relation.journalcode | J01150 | - |
dc.identifier.eissn | 1873-3476 | - |
dc.identifier.pmid | 31022502 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S037851731930328X | - |
dc.subject.keyword | 1-Ethyl-3-(3-(dimethylaminopropyl)carbodi-imide (PubChem CID: 15908) | - |
dc.subject.keyword | Adipic acid dihydrazide (PubChem CID: 66117) | - |
dc.subject.keyword | Carboxymethyl cellulose sodium | - |
dc.subject.keyword | Carboxymethyl cellulose sodium (PubChem CID: 23706213) | - |
dc.subject.keyword | Colorectal cancer | - |
dc.subject.keyword | Hyaluronic acid | - |
dc.subject.keyword | Hyaluronic acid (PubChem CID: 24847767) | - |
dc.subject.keyword | Hyaluronidase (CAS Number 91820602) | - |
dc.subject.keyword | Hydrogel | - |
dc.subject.keyword | Intra-abdominal anti-adhesion barrier | - |
dc.subject.keyword | Oxaliplatin | - |
dc.contributor.alternativeName | Park, Eun Jung | - |
dc.contributor.affiliatedAuthor | 박은정 | - |
dc.contributor.affiliatedAuthor | 백승혁 | - |
dc.contributor.affiliatedAuthor | 전영배 | - |
dc.citation.volume | 565 | - |
dc.citation.startPage | 50 | - |
dc.citation.endPage | 58 | - |
dc.identifier.bibliographicCitation | International Journal of Pharmaceutics, Vol.565 : 50-58, 2019 | - |
dc.identifier.rimsid | 63313 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.