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Oxaliplatin-loaded chemically cross-linked hydrogels for prevention of postoperative abdominal adhesion and colorectal cancer therapy

 Jee Eun Lee  ;  Sharif Md Abuzar  ;  Yeji Seo  ;  Hyeji Han  ;  Youngbae Jeon  ;  Eun Jung Park  ;  Seung Hyuk Baik  ;  Sung-Joo Hwang 
 International Journal of Pharmaceutics, Vol.565 : 50-58, 2019 
Journal Title
 International Journal of Pharmaceutics 
Issue Date
1-Ethyl-3-(3-(dimethylaminopropyl)carbodi-imide (PubChem CID: 15908) ; Adipic acid dihydrazide (PubChem CID: 66117) ; Carboxymethyl cellulose sodium ; Carboxymethyl cellulose sodium (PubChem CID: 23706213) ; Colorectal cancer ; Hyaluronic acid ; Hyaluronic acid (PubChem CID: 24847767) ; Hyaluronidase (CAS Number 91820602) ; Hydrogel ; Intra-abdominal anti-adhesion barrier ; Oxaliplatin
Colorectal cancer (CRC) is the third most commonly diagnosed cancer among both men and women worldwide. New therapeutic strategies involving cytoreductive surgery and intra-peritoneal chemotherapy could lead to a definitive cure in some cases. However, postoperative intra-abdominal adhesion can cause further complications. In this study, hyaluronic acid (HA)- and carboxymethyl cellulose sodium (CMCNa)-based novel cross-linked hydrogels (HC hydrogels) were synthesized and fully characterized. We demonstrated that varied compositions of HA and CMCNa altered the microstructure, rheology, and degradation behavior of hydrogels. Pre-constructed hydrogels were further loaded with oxaliplatin to prevent intra-abdominal adhesion following chemotherapy. Sustained release of oxaliplatin was observed from hydrogels compared that from solutions, which release drugs through diffusion, following the Higuchi and Korsmeyer-Peppas models. Moreover, low adhesion scores in an in vivo SD rat model demonstrated inhibition of intra-peritoneal adhesion in response to HC hydrogels. Therefore, HC hydrogels offer a novel formulation strategy for providing an intra-abdominal anti-adhesion barrier after cytoreductive surgery and intra-peritoneal chemotherapy for CRC treatment.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Eun Jung(박은정) ORCID logo https://orcid.org/0000-0002-4559-2690
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Jeon, Youngbae(전영배)
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