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HIC2, a new transcription activator of SIRT1

Authors
 Ji‐Yang Song  ;  Seung‐Hyun Lee  ;  Min‐Kyeong Kim  ;  Bu‐Nam Jeon  ;  Su‐Yeon Cho  ;  Sun‐Ho Lee  ;  Kyung‐Sup Kim  ;  Man‐Wook Hur 
Citation
 FEBS Letters, Vol.593(14) : 1763-1776, 2019 
Journal Title
 FEBS Letters 
ISSN
 0014-5793 
Issue Date
2019
Keywords
HIC1 ; HIC2 ; SIRT1 ; heart ; ischemia/reperfusion injury ; transcription
Abstract
The protein deacetylase SIRT1 is crucial to numerous physiological processes, such as aging, metabolism, and autoimmunity, and is repressed by various transcription factors, including HIC1. Conversely, we found that HIC2, which is highly homologous to HIC1, is a transcriptional activator of SIRT1 due to opposite activity of the intermediate domains of the two homologs. Importantly, this relationship between HIC2 and SIRT1 could be important for cardiac development, where both proteins are implicated. Here, we assessed whether ectopic expression of HIC2, and subsequent upregulation of SIRT1, might decrease apoptosis in H9c2 cardiomyocytes under simulated ischemia/reperfusion (I/R) injury conditions. Our results demonstrate that unlike its structural homolog HIC1, HIC2 is a pivotal transcriptional activator of SIRT1 and, consequently, may protect the heart from I/R injury.
Full Text
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13456
DOI
10.1002/1873-3468.13456
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sup(김경섭) ORCID logo https://orcid.org/0000-0001-8483-8537
Lee, Seung Hyun(이승현) ORCID logo https://orcid.org/0000-0001-7549-9430
Jeon, Bu Nam(전부남)
Hur, Man Wook(허만욱) ORCID logo https://orcid.org/0000-0002-3416-1334
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171063
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